Anti-inflammatory Effect of Resveratrol and Polydatin by In Vitro IL-17 Modulation

Interleukin-17 (IL-17) is a proinflammatory cytokine produced, although not exclusively, by T helper 17 recently identified as a distinct T helper lineage mediating tissue inflammation. IL-17 is known to be involved in a number of chronic disorders although the mechanisms regulating its production i...

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Bibliographic Details
Published in:Inflammation 2012-02, Vol.35 (1), p.240-248
Main Authors: Lanzilli, Giulia, Cottarelli, Andrea, Nicotera, Giuseppe, Guida, Serena, Ravagnan, Giampiero, Fuggetta, Maria Pia
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Biomedical and Life Sciences
Biomedicine
CD28 Antigens - immunology
CD3 Complex - immunology
Cells, Cultured
Drugs, Chinese Herbal - pharmacology
Glucosides - pharmacology
Humans
Immunology
Interleukin-17 - metabolism
Internal Medicine
Leukocytes, Mononuclear - immunology
Leukocytes, Mononuclear - metabolism
Pathology
Pharmacology/Toxicology
Rheumatology
RNA, Messenger - biosynthesis
Stilbenes - pharmacology
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Summary:Interleukin-17 (IL-17) is a proinflammatory cytokine produced, although not exclusively, by T helper 17 recently identified as a distinct T helper lineage mediating tissue inflammation. IL-17 is known to be involved in a number of chronic disorders although the mechanisms regulating its production in inflammatory disease are still unclear. The beneficial properties of the polyphenolic compound resveratrol including its anti-inflammatory, antioxidant, and antitumor effects, its role in the aging process and in the prevention of heart and neurodegenerative diseases are well-known. In addition, derivatives of resveratrol, including glucosylated molecules as polydatin have been linked to similar beneficial effects. We have investigated the effects of resveratrol and polydatin on the in vitro production of IL-17 in a model of inflammation in vitro . The results obtained by activated human peripheral blood mononuclear cells, stimulated with anti-CD3/anti-CD28 monoclonal antibodies and treated with these polyphenolic compounds at different concentrations show that both decrease IL-17 production in a concentration-dependent manner. This study confirms the anti-inflammatory activity of resveratrol and its derivatives and suggests a potential clinical relevance in the therapy of inflammatory diseases.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-011-9310-z