Growth factors and chondrogenic differentiation of mesenchymal stem cells

Abstract The main purpose of the article is to review recent knowledge about growth factors and their effect on the chondrogenic differentiation of mesenchymal stem cells under in vitro conditions. Damaged or lost articular cartilage leads to progressive debilitation, which have major impact on the...

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Bibliographic Details
Published in:Tissue & cell 2012-04, Vol.44 (2), p.69-73
Main Authors: Danišovič, Ľ, Varga, I, Polák, Š
Format: Article
Language:English
Subjects:
Advanced Basic Science
Age
Cartilage (articular)
Cartilage diseases
Cell Differentiation
Cell Proliferation
Chondrocytes
Chondrocytes - cytology
Chondrocytes - metabolism
Chondrogenesis
Chondrogenic differentiation
Debilitation
Differentiation
Fibroblast Growth Factors - pharmacology
Fibroblast Growth Factors - therapeutic use
Growth factors
Humans
Hyaline Cartilage - pathology
Hyaline Cartilage - transplantation
Innervation
Insulin-Like Growth Factor I - metabolism
Insulin-Like Growth Factor I - therapeutic use
Limiting factors
Mesenchymal Stem Cell Transplantation
Mesenchymal stem cells
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - metabolism
Mesenchyme
Osteoarthritis
Osteoarthritis - pathology
Osteoarthritis - therapy
Sex
Stem cells
Transforming Growth Factor beta - metabolism
Transforming Growth Factor beta - therapeutic use
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Summary:Abstract The main purpose of the article is to review recent knowledge about growth factors and their effect on the chondrogenic differentiation of mesenchymal stem cells under in vitro conditions. Damaged or lost articular cartilage leads to progressive debilitation, which have major impact on the life quality of the affected individuals of both sexes in all age groups. Mature hyaline cartilage has a very low self-repair potential due to intrinsic properties – lack of innervation and vascular supply. Another limiting factor is low mitotic potential of chondrocytes. Small defects are healed by migration of chondrocytes, while large ones are healed by formation of inferior fibrocartilage. However, in many cases osteoarthritis develops. Recently, cellular therapy combining mesenchymal stem cells and proper differentiation factors seems to be promising tool for hyaline cartilage defects healing.
ISSN:0040-8166
1532-3072
DOI:10.1016/j.tice.2011.11.005