Association between quality of life and clinical parameters in patients with myeloproliferative neoplasms

Abstract The Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) is a validated quality of life (QoL) instrument. In our Swedish cohort of 114 patients the symptomatic burden was found to be severe, with fatigue reported in 88% of the patients and reduced QoL in the majority of patients. P...

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Bibliographic Details
Published in:Leukemia & lymphoma 2012-03, Vol.53 (3), p.441-444
Main Authors: Johansson, Peter, Mesa, Ruben, Scherber, Robyn, Abelsson, Johanna, Samuelsson, Jan, Birgegård, Gunnar, Andréasson, Björn
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Anorexia - etiology
Anorexia - psychology
Fatigue - etiology
Fatigue - psychology
Female
Hemoglobins - analysis
Humans
Male
Medicin och hälsovetenskap
Middle Aged
Mood Disorders - classification
Mood Disorders - etiology
Mood Disorders - psychology
Myeloproliferative Disorders - blood
Myeloproliferative Disorders - complications
Myeloproliferative Disorders - psychology
myeloproliferative neoplasms
Nervous System Diseases - etiology
Nervous System Diseases - psychology
Pain - etiology
Pain - psychology
Quality of Life
Sexual Dysfunction, Physiological - etiology
Sexual Dysfunction, Physiological - psychology
Surveys and Questionnaires
Sweden
Weight Loss
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Summary:Abstract The Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF) is a validated quality of life (QoL) instrument. In our Swedish cohort of 114 patients the symptomatic burden was found to be severe, with fatigue reported in 88% of the patients and reduced QoL in the majority of patients. Patients with primary myelofibrosis had the highest scores, low QoL, for most MPN-SAF items, compared to patients with polycythemia vera and essential thrombocythemia. Higher age showed significant associations with the BFI (Brief Fatigue Inventory) score, early satiety, concentration problems, dizziness, insomnia, cough and weight loss. Blood values, disease duration and myelosuppressive treatment did not significantly associate with any of the MPN-SAF items, with the exception of higher hemoglobin, which correlated with sad mood. Male patients with MPN scored significantly higher as regards sexual problems and weight loss compared to female patients. Overall, the MPN-SAF was found to be a valid instrument for assessing symptomatic burden among this population.
ISSN:1042-8194
1029-2403
1029-2403
DOI:10.3109/10428194.2011.619608