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A preliminary study on the FAM5C expression in generalized chronic periodontitis
Oral Diseases (2012) 18, 147–152 Objective: The Family with sequence similarity 5 member C (FAM5C) has been suggested to contribute in aggressive periodontitis. However, there is no data regarding its role in chronic periodontitis. The aim of this study was to evaluate the FAM5C expression in chron...
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| Published in: | Oral diseases 2012-03, Vol.18 (2), p.147-152 |
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| container_start_page | 147 |
| container_title | Oral diseases |
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| creator | Ribeiro, FV Santos, VR Bastos, MF de Miranda, TS Vieira, AR de Figueiredo, LC Duarte, PM |
| description | Oral Diseases (2012) 18, 147–152
Objective: The Family with sequence similarity 5 member C (FAM5C) has been suggested to contribute in aggressive periodontitis. However, there is no data regarding its role in chronic periodontitis. The aim of this study was to evaluate the FAM5C expression in chronic periodontitis and to study association of FAM5C with key immunoinflammatory markers.
Material and Methods: Gingival biopsies were harvested from periodontally healthy subjects (n = 10) and chronic periodontitis subjects (n = 15). The levels of mRNA of FAM5C, interleukin (IL)‐17, IL‐6, IL‐23, IL‐10, IL‐4, interferon‐γ, toll‐like receptor (TLR)‐2, TLR‐4, osteoprotegerin (OPG), receptor activator of NF‐κB ligand (RANKL), tumor necrosis factor (TNF)‐α, transforming growth factor‐β, transcription factor forkhead box p3, and transcription factor orphan nuclear receptor C2 were evaluated by real‐time polymerase chain reaction.
Results: FAM5C mRNA levels were not different between periodontally healthy and diseased tissues (P > 0.05). Gene expressions of IL‐17, TNF‐α, OPG, RANKL, TLR‐2, and TLR‐4 were higher in periodontitis, when compared to periodontally healthy sites (P 0.05). There were no correlations between the gene expression of FAM5C and the other immunoinflammatory markers (P > 0.05).
Conclusion: Within the limits of this study, it seems that FAM5C expression does not contribute to chronic periodontitis. |
| doi_str_mv | 10.1111/j.1601-0825.2011.01855.x |
| format | article |
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Objective: The Family with sequence similarity 5 member C (FAM5C) has been suggested to contribute in aggressive periodontitis. However, there is no data regarding its role in chronic periodontitis. The aim of this study was to evaluate the FAM5C expression in chronic periodontitis and to study association of FAM5C with key immunoinflammatory markers.
Material and Methods: Gingival biopsies were harvested from periodontally healthy subjects (n = 10) and chronic periodontitis subjects (n = 15). The levels of mRNA of FAM5C, interleukin (IL)‐17, IL‐6, IL‐23, IL‐10, IL‐4, interferon‐γ, toll‐like receptor (TLR)‐2, TLR‐4, osteoprotegerin (OPG), receptor activator of NF‐κB ligand (RANKL), tumor necrosis factor (TNF)‐α, transforming growth factor‐β, transcription factor forkhead box p3, and transcription factor orphan nuclear receptor C2 were evaluated by real‐time polymerase chain reaction.
Results: FAM5C mRNA levels were not different between periodontally healthy and diseased tissues (P > 0.05). Gene expressions of IL‐17, TNF‐α, OPG, RANKL, TLR‐2, and TLR‐4 were higher in periodontitis, when compared to periodontally healthy sites (P < 0.05), while no differences between groups were observed for the other genes evaluated (P > 0.05). There were no correlations between the gene expression of FAM5C and the other immunoinflammatory markers (P > 0.05).
Conclusion: Within the limits of this study, it seems that FAM5C expression does not contribute to chronic periodontitis.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/j.1601-0825.2011.01855.x</identifier><identifier>PMID: 22355820</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Case-Control Studies ; chronic periodontitis ; Chronic Periodontitis - genetics ; Chronic Periodontitis - metabolism ; cytokines ; Cytokines - biosynthesis ; Cytokines - genetics ; Dentistry ; DNA-Binding Proteins - biosynthesis ; DNA-Binding Proteins - genetics ; FAM5C protein ; FAM5C protein, human ; Female ; Gene Expression ; Gingiva - pathology ; human ; Humans ; Inflammation Mediators - metabolism ; Interleukins - biosynthesis ; Interleukins - genetics ; Male ; Medical research ; Middle Aged ; Mitochondrial Proteins - biosynthesis ; Mitochondrial Proteins - genetics ; Periodontal Index ; Pilot Projects ; polymerase chain reaction ; RANK Ligand - biosynthesis ; RANK Ligand - genetics ; Real-Time Polymerase Chain Reaction ; RNA, Messenger - genetics ; Statistics, Nonparametric ; Toll-Like Receptor 2 - biosynthesis ; Toll-Like Receptor 2 - genetics ; Toll-Like Receptor 4 - biosynthesis ; Toll-Like Receptor 4 - genetics ; Transcription factors ; Tumor Necrosis Factor-alpha - biosynthesis ; Tumor Necrosis Factor-alpha - genetics</subject><ispartof>Oral diseases, 2012-03, Vol.18 (2), p.147-152</ispartof><rights>2011 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5005-f70af2e9351fff2b3435f800f553bd1ce8e66e01e928706fc54b863bdbc0df23</citedby><cites>FETCH-LOGICAL-c5005-f70af2e9351fff2b3435f800f553bd1ce8e66e01e928706fc54b863bdbc0df23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22355820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ribeiro, FV</creatorcontrib><creatorcontrib>Santos, VR</creatorcontrib><creatorcontrib>Bastos, MF</creatorcontrib><creatorcontrib>de Miranda, TS</creatorcontrib><creatorcontrib>Vieira, AR</creatorcontrib><creatorcontrib>de Figueiredo, LC</creatorcontrib><creatorcontrib>Duarte, PM</creatorcontrib><title>A preliminary study on the FAM5C expression in generalized chronic periodontitis</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Oral Diseases (2012) 18, 147–152
Objective: The Family with sequence similarity 5 member C (FAM5C) has been suggested to contribute in aggressive periodontitis. However, there is no data regarding its role in chronic periodontitis. The aim of this study was to evaluate the FAM5C expression in chronic periodontitis and to study association of FAM5C with key immunoinflammatory markers.
Material and Methods: Gingival biopsies were harvested from periodontally healthy subjects (n = 10) and chronic periodontitis subjects (n = 15). The levels of mRNA of FAM5C, interleukin (IL)‐17, IL‐6, IL‐23, IL‐10, IL‐4, interferon‐γ, toll‐like receptor (TLR)‐2, TLR‐4, osteoprotegerin (OPG), receptor activator of NF‐κB ligand (RANKL), tumor necrosis factor (TNF)‐α, transforming growth factor‐β, transcription factor forkhead box p3, and transcription factor orphan nuclear receptor C2 were evaluated by real‐time polymerase chain reaction.
Results: FAM5C mRNA levels were not different between periodontally healthy and diseased tissues (P > 0.05). Gene expressions of IL‐17, TNF‐α, OPG, RANKL, TLR‐2, and TLR‐4 were higher in periodontitis, when compared to periodontally healthy sites (P < 0.05), while no differences between groups were observed for the other genes evaluated (P > 0.05). There were no correlations between the gene expression of FAM5C and the other immunoinflammatory markers (P > 0.05).
Conclusion: Within the limits of this study, it seems that FAM5C expression does not contribute to chronic periodontitis.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>chronic periodontitis</subject><subject>Chronic Periodontitis - genetics</subject><subject>Chronic Periodontitis - metabolism</subject><subject>cytokines</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - genetics</subject><subject>Dentistry</subject><subject>DNA-Binding Proteins - biosynthesis</subject><subject>DNA-Binding Proteins - genetics</subject><subject>FAM5C protein</subject><subject>FAM5C protein, human</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Gingiva - pathology</subject><subject>human</subject><subject>Humans</subject><subject>Inflammation Mediators - metabolism</subject><subject>Interleukins - biosynthesis</subject><subject>Interleukins - genetics</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Mitochondrial Proteins - biosynthesis</subject><subject>Mitochondrial Proteins - genetics</subject><subject>Periodontal Index</subject><subject>Pilot Projects</subject><subject>polymerase chain reaction</subject><subject>RANK Ligand - biosynthesis</subject><subject>RANK Ligand - genetics</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>Statistics, Nonparametric</subject><subject>Toll-Like Receptor 2 - biosynthesis</subject><subject>Toll-Like Receptor 2 - genetics</subject><subject>Toll-Like Receptor 4 - biosynthesis</subject><subject>Toll-Like Receptor 4 - genetics</subject><subject>Transcription factors</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNkE1v1DAQhi0EoqXwF5AlDpySju1M4hw4rBb6gQqlUgWIi5WPMfWSTRY7Ebv8-jps2QMnfPHI87wz1sMYF5CKeE5XqchBJKAlphKESEFoxHT7iB0fGo9jrTBLUKqvR-xZCCsAUZRKPmVHUipELeGYfVrwjafOrV1f-R0P49Tu-NDz8Y742eIDLjltIxCCi4-u59-pJ1917je1vLnzQ-8aviHvhnboRze68Jw9sVUX6MXDfcJuz97dLi-Sq-vzy-XiKmkQABNbQGUllQqFtVbWKlNoNYBFVHUrGtKU5wSCSqkLyG2DWa3z2KobaK1UJ-z1fuzGDz8nCqNZu9BQ11U9DVMwpVRCl1JAJF_9Q66Gyffxb0ZghiLPZDFTek81fgjBkzUb79ZRiRFgZudmZWa1ZlZrZufmj3OzjdGXDwumek3tIfhXcgTe7IFfrqPdfw82128v5yrmk33ehZG2h3zlf5i8UAWaLx_Pzc3N-wv9-dvSlOoetoieWQ</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Ribeiro, FV</creator><creator>Santos, VR</creator><creator>Bastos, MF</creator><creator>de Miranda, TS</creator><creator>Vieira, AR</creator><creator>de Figueiredo, LC</creator><creator>Duarte, PM</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201203</creationdate><title>A preliminary study on the FAM5C expression in generalized chronic periodontitis</title><author>Ribeiro, FV ; Santos, VR ; Bastos, MF ; de Miranda, TS ; Vieira, AR ; de Figueiredo, LC ; Duarte, PM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5005-f70af2e9351fff2b3435f800f553bd1ce8e66e01e928706fc54b863bdbc0df23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>chronic periodontitis</topic><topic>Chronic Periodontitis - genetics</topic><topic>Chronic Periodontitis - metabolism</topic><topic>cytokines</topic><topic>Cytokines - biosynthesis</topic><topic>Cytokines - genetics</topic><topic>Dentistry</topic><topic>DNA-Binding Proteins - biosynthesis</topic><topic>DNA-Binding Proteins - genetics</topic><topic>FAM5C protein</topic><topic>FAM5C protein, human</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Gingiva - pathology</topic><topic>human</topic><topic>Humans</topic><topic>Inflammation Mediators - metabolism</topic><topic>Interleukins - biosynthesis</topic><topic>Interleukins - genetics</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Mitochondrial Proteins - biosynthesis</topic><topic>Mitochondrial Proteins - genetics</topic><topic>Periodontal Index</topic><topic>Pilot Projects</topic><topic>polymerase chain reaction</topic><topic>RANK Ligand - biosynthesis</topic><topic>RANK Ligand - genetics</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>Statistics, Nonparametric</topic><topic>Toll-Like Receptor 2 - biosynthesis</topic><topic>Toll-Like Receptor 2 - genetics</topic><topic>Toll-Like Receptor 4 - biosynthesis</topic><topic>Toll-Like Receptor 4 - genetics</topic><topic>Transcription factors</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ribeiro, FV</creatorcontrib><creatorcontrib>Santos, VR</creatorcontrib><creatorcontrib>Bastos, MF</creatorcontrib><creatorcontrib>de Miranda, TS</creatorcontrib><creatorcontrib>Vieira, AR</creatorcontrib><creatorcontrib>de Figueiredo, LC</creatorcontrib><creatorcontrib>Duarte, PM</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ribeiro, FV</au><au>Santos, VR</au><au>Bastos, MF</au><au>de Miranda, TS</au><au>Vieira, AR</au><au>de Figueiredo, LC</au><au>Duarte, PM</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A preliminary study on the FAM5C expression in generalized chronic periodontitis</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2012-03</date><risdate>2012</risdate><volume>18</volume><issue>2</issue><spage>147</spage><epage>152</epage><pages>147-152</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Oral Diseases (2012) 18, 147–152
Objective: The Family with sequence similarity 5 member C (FAM5C) has been suggested to contribute in aggressive periodontitis. However, there is no data regarding its role in chronic periodontitis. The aim of this study was to evaluate the FAM5C expression in chronic periodontitis and to study association of FAM5C with key immunoinflammatory markers.
Material and Methods: Gingival biopsies were harvested from periodontally healthy subjects (n = 10) and chronic periodontitis subjects (n = 15). The levels of mRNA of FAM5C, interleukin (IL)‐17, IL‐6, IL‐23, IL‐10, IL‐4, interferon‐γ, toll‐like receptor (TLR)‐2, TLR‐4, osteoprotegerin (OPG), receptor activator of NF‐κB ligand (RANKL), tumor necrosis factor (TNF)‐α, transforming growth factor‐β, transcription factor forkhead box p3, and transcription factor orphan nuclear receptor C2 were evaluated by real‐time polymerase chain reaction.
Results: FAM5C mRNA levels were not different between periodontally healthy and diseased tissues (P > 0.05). Gene expressions of IL‐17, TNF‐α, OPG, RANKL, TLR‐2, and TLR‐4 were higher in periodontitis, when compared to periodontally healthy sites (P < 0.05), while no differences between groups were observed for the other genes evaluated (P > 0.05). There were no correlations between the gene expression of FAM5C and the other immunoinflammatory markers (P > 0.05).
Conclusion: Within the limits of this study, it seems that FAM5C expression does not contribute to chronic periodontitis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22355820</pmid><doi>10.1111/j.1601-0825.2011.01855.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Case-Control Studies chronic periodontitis Chronic Periodontitis - genetics Chronic Periodontitis - metabolism cytokines Cytokines - biosynthesis Cytokines - genetics Dentistry DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics FAM5C protein FAM5C protein, human Female Gene Expression Gingiva - pathology human Humans Inflammation Mediators - metabolism Interleukins - biosynthesis Interleukins - genetics Male Medical research Middle Aged Mitochondrial Proteins - biosynthesis Mitochondrial Proteins - genetics Periodontal Index Pilot Projects polymerase chain reaction RANK Ligand - biosynthesis RANK Ligand - genetics Real-Time Polymerase Chain Reaction RNA, Messenger - genetics Statistics, Nonparametric Toll-Like Receptor 2 - biosynthesis Toll-Like Receptor 2 - genetics Toll-Like Receptor 4 - biosynthesis Toll-Like Receptor 4 - genetics Transcription factors Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics |
| title | A preliminary study on the FAM5C expression in generalized chronic periodontitis |
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