Loading…

Design and synthesis of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors

Monoamine oxidase-B (MAO-B) inhibitor has been used as neuroprotectants to treat the motor deficits of Parkinson‘s disease (PD). We designed and synthesized a class of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors. The compounds have various inhibitory effects, with compound...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2012-02, Vol.22 (4), p.1739-1742
Main Authors: Song, Bo, Xiao, Tong, Qi, Xiaolu, Li, Ling-Na, Qin, Kuiyou, Nian, Siyun, Hu, Guo-Xin, Yu, Yinfei, Liang, Guang, Ye, Faqing
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Monoamine oxidase-B (MAO-B) inhibitor has been used as neuroprotectants to treat the motor deficits of Parkinson‘s disease (PD). We designed and synthesized a class of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors. The compounds have various inhibitory effects, with compound 6a having a Ki value of 0.26μM. Their promising activity in vitro suggests potential use in the treatment of PD.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2011.12.094