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Design and synthesis of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors
Monoamine oxidase-B (MAO-B) inhibitor has been used as neuroprotectants to treat the motor deficits of Parkinson‘s disease (PD). We designed and synthesized a class of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors. The compounds have various inhibitory effects, with compound...
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Published in: | Bioorganic & medicinal chemistry letters 2012-02, Vol.22 (4), p.1739-1742 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Monoamine oxidase-B (MAO-B) inhibitor has been used as neuroprotectants to treat the motor deficits of Parkinson‘s disease (PD). We designed and synthesized a class of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors. The compounds have various inhibitory effects, with compound 6a having a Ki value of 0.26μM. Their promising activity in vitro suggests potential use in the treatment of PD. |
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ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2011.12.094 |