MicroRNAs and Type 2 Diabetes/Obesity

MicroRNAs belong to a newly identified class of small non-coding RNAs that have been widely implicated in the fine-tuning of many physiological processes such as the pathogenesis of type 2 diabetes (T2D) and obesity. Microarray studies have highlighted an altered profile of miRNA expression in insul...

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Bibliographic Details
Published in:Journal of genetics and genomics 2012, Vol.39 (1), p.11-18
Main Authors: Dehwah, Mustafa Abdo Saif, Xu, Aimin, Huang, Qingyang
Format: Article
Language:English
Subjects:
2型糖尿病
Animals
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
early diagnosis
Gene Expression Regulation
glucose
homeostasis
Humans
insulin
microarray technology
microRNA
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
noninsulin-dependent diabetes mellitus
Obesity
Obesity - genetics
Obesity - metabolism
Obesity - pathology
pathogenesis
secretion
Type 2 diabetes
小分子RNA
生理过程
组织特异性
肥胖
脂肪细胞分化
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Summary:MicroRNAs belong to a newly identified class of small non-coding RNAs that have been widely implicated in the fine-tuning of many physiological processes such as the pathogenesis of type 2 diabetes (T2D) and obesity. Microarray studies have highlighted an altered profile of miRNA expression in insulin target tissues in diabetic and obese models. Emerging evidences suggest that miRNAs play significant roles in insulin production, secretion and actions, as well as in diverse aspects of glucose homeostasis and adipocyte differentiation. The identification of tissue-specific miRNAs implicated in T2D and obesity might be useful for the future development of effective strategies for early diagnosis and therapeutic intervention of obesity-related medical complications.
ISSN:1673-8527
DOI:10.1016/j.jgg.2011.11.007