Nasopharyngeal carcinoma： Advances in genomics and molecular genetics

Nasopharyngeal carcinoma （NPC） is a squamous-cell carcinoma that arises in the epithelial lining of the nasopharynx [1]. This neoplasm has a notable ethnic and geographic distribution, being of high prevalence in southern China but rare in other parts of the world [2]. Familial clustering of NPC has...

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Bibliographic Details
Published in:Science China. Life sciences 2011-10, Vol.54 (10), p.966-975
Main Authors: Zeng, ZhaoYang, Huang, HongBin, Zhang, WenLing, Xiang, Bo, Zhou, Ming, Zhou, YanHong, Ma, Jian, Yi, Mei, Li, XiaYu, Li, XiaoLing, Xiong, Wei, Li, GuiYuan
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Cell Transformation, Neoplastic - genetics
EB病毒
Epigenesis, Genetic
Epstein-Barr virus
Genome-Wide Association Study
Genomics
Herpesvirus 4, Human - pathogenicity
Humans
Insight
Life Sciences
Nasopharyngeal Neoplasms - genetics
Nasopharyngeal Neoplasms - microbiology
Nasopharyngeal Neoplasms - virology
Proteomics
Risk Factors
Transcriptome
全国人民代表大会
分子遗传学
地域分布
基因组学
病毒DNA
鳞状细胞癌
鼻咽癌
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Summary:Nasopharyngeal carcinoma （NPC） is a squamous-cell carcinoma that arises in the epithelial lining of the nasopharynx [1]. This neoplasm has a notable ethnic and geographic distribution, being of high prevalence in southern China but rare in other parts of the world [2]. Familial clustering of NPC has been observed in diverse populations [3]. Elevated levels of circulating free Epstein-Barr virus （EBV） DNA and EBV-related antibodies in sera, as well as EBV DNA in tumor ceils, have been consistently detected in individuals with NPC [4,5].
ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-011-4223-5