Dynamic expression of the LAP family of genes during early development of Xenopus tropicalis

The leucine-rich repeats and PDZ （LAP） family of genes are crucial for the maintenance of cell polarity as well as for epithelial homeostasis and tumor suppression in both vertebrates and invertebrates. Four members of this gene family are known： densin, erbin, scribble and lano. Here, we identified...

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Bibliographic Details
Published in:Science China. Life sciences 2011-10, Vol.54 (10), p.897-903
Main Authors: Yang, QiuTan, Lv, XiaoYan, Kong, QingHua, Li, ChaoCui, Zhou, Qin, Mao, BingYu
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Biomedical and Life Sciences
Carrier Proteins - genetics
DNA Primers
Gene Expression Regulation, Developmental
In Situ Hybridization
LAP
Life Sciences
Membrane Proteins - genetics
Phylogeny
Polymerase Chain Reaction
Research Papers
Xenopus
Xenopus - embryology
Xenopus - genetics
Xenopus tropicalis
动态表
基因家族
无脊椎动物
早期发育过程
热带
胚胎发育过程
非洲爪蟾
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Summary:The leucine-rich repeats and PDZ （LAP） family of genes are crucial for the maintenance of cell polarity as well as for epithelial homeostasis and tumor suppression in both vertebrates and invertebrates. Four members of this gene family are known： densin, erbin, scribble and lano. Here, we identified the four members of the LAP gene family in Xenopus tropicalis and studied their expression patterns during embryonic development. The Xenopus LAP proteins show a conserved domain structure that is similar to their homologs in other vertebrates. In Xenopus embryos, these genes were detected in animal cap cells at the early gastrula stage. At later stages of development, they were widely expressed in epithelial tissues that are highly polar in nature, including the neural epithelia, optic and otic vesicles, and in the pronephros. These data suggest that the roles of the Xenopus LAP genes in the control of cell polarity and morphogenesis are conserved during early development. Erbin and lano show similar expression patterns in the developing head, suggesting potential functional interactions between the two molecules in vivo.
ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-011-4224-4