Prevalence of Small Intestinal Bacterial Overgrowth in Parkinson's Disease

Background: Parkinson's disease (PD) is associated with gastrointestinal motility abnormalities that could favor the occurrence of small intestinal bacterial overgrowth. The aim of the study was to assess the prevalence of small intestinal bacterial overgrowth in PD patients. Methods: Consecuti...

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Published in:Movement disorders 2011-04, Vol.26 (5), p.889-892
Main Authors: Gabrielli, Maurizio, Bonazzi, Patrizia, Scarpellini, Emidio, Bendia, Emanuele, Lauritano, Ernesto C., Fasano, Alfonso, Ceravolo, Maria G., Capecci, Marianna, Rita Bentivoglio, Anna, Provinciali, Leandro, Tonali, Pietro A., Gasbarrini, Antonio
Format: Article
Language:English
Subjects:
Aged
Bacteria
Bacterial Infections - complications
Bacterial Infections - epidemiology
Female
glucose breath test
gut flora
Humans
Intestinal Diseases - complications
Intestinal Diseases - epidemiology
Intestinal Diseases - pathology
Intestine, Small - microbiology
Intestine, Small - pathology
Male
Middle Aged
Parkinson Disease - epidemiology
Parkinson's disease
small intestinal bacterial overgrowth
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Summary:Background: Parkinson's disease (PD) is associated with gastrointestinal motility abnormalities that could favor the occurrence of small intestinal bacterial overgrowth. The aim of the study was to assess the prevalence of small intestinal bacterial overgrowth in PD patients. Methods: Consecutive PD patients were enrolled. The controls were subjects without PD. All patients and controls underwent the glucose breath test to assess small intestinal bacterial overgrowth. Results: Forty‐eight PD patients and 36 controls were enrolled. The prevalence of small intestinal bacterial overgrowth was significantly higher in PD patients than in controls (54.17% vs 8.33%; P < .0001; OR, 2.24; 95% CI, 3.50–48.24). Multivariate analysis showed Hoehn and Yahr stage (OR, 3.07; 95% CI, 1.14–8.27) and Unified PD Rating score (OR, 1.12; 95% CI, 1.02–1.23) were significantly associated with small intestinal bacterial overgrowth in PD patients. Conclusions: Small intestinal bacterial overgrowth is highly prevalent in PD. Gastrointestinal motility abnormalities might explain this association. © 2011 Movement Disorder Society
ISSN:0885-3185
1531-8257
1531-8257
DOI:10.1002/mds.23566