The expression and role of CXC chemokines in colorectal cancer

Abstract Cancer is a life-threatening disease world-wide and colorectal cancer is the second common cause of cancer mortality. The interaction between tumor cells and stromal cells plays a crucial role in tumor initiation and progression and is partially mediated by chemokines. Chemokines predominan...

Full description

Saved in:
Bibliographic Details
Published in:Cytokine & growth factor reviews 2011-10, Vol.22 (5), p.345-358
Main Authors: Verbeke, Hannelien, Struyf, Sofie, Laureys, Geneviève, Van Damme, Jo
Format: Article
Language:English
Subjects:
Advanced Basic Science
Angiogenesis
Chemokine
Colorectal cancer
Leukocyte
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Cancer is a life-threatening disease world-wide and colorectal cancer is the second common cause of cancer mortality. The interaction between tumor cells and stromal cells plays a crucial role in tumor initiation and progression and is partially mediated by chemokines. Chemokines predominantly participate in the chemoattraction of leukocytes to inflammatory sites. Nowadays, it is clear that CXC chemokines and their receptors (CXCR) may also modulate tumor behavior by several important mechanisms: regulation of angiogenesis, activation of a tumor-specific immune response by attracting leukocytes, stimulation of tumor cell proliferation and metastasis. Here, we review the expression and complex roles of CXC chemokines (CXCL1 to CXCL16) and their receptors (CXCR1 to CXCR6) in colorectal cancer. Overall, increased expression levels of CXC chemokines correlate with poor prognosis.
ISSN:1359-6101
DOI:10.1016/j.cytogfr.2011.09.002