Comparative assessment of a DNA and protein Leishmania donovani gamma glutamyl cysteine synthetase vaccine to cross-protect against murine cutaneous leishmaniasis caused by L. major or L. mexicana infection

• Published in: Vaccine 2012-02, Vol.30 (7), p.1357-1363
• Main Authors: Campbell, S.A, Alawa, J, Doro, B, Henriquez, F.L, Roberts, C.W, Nok, A, Alawa, C.B.I, Alsaadi, M, Mullen, A.B, Carter, K.C
• Format: Article
• Language: English
• Subjects: Allergy and Immunology; Animals; Antibodies, Protozoan - biosynthesis; Antibodies, Protozoan - immunology; Antigens, Protozoan - genetics; Antigens, Protozoan - immunology; Cross Protection; cutaneous leishmaniasis; cysteine; disease control; DNA; Epitopes; Gamma glutamyl cysteine synthetase; Glutamate-Cysteine Ligase - genetics; Glutamate-Cysteine Ligase - immunology; Humans; Leishmania; Leishmania donovani; Leishmania donovani - immunology; Leishmania major - immunology; Leishmania mexicana - immunology; Leishmaniasis Vaccines - genetics; Leishmaniasis Vaccines - immunology; Leishmaniasis, Cutaneous - immunology; Leishmaniasis, Cutaneous - parasitology; Leishmaniasis, Cutaneous - prevention & control; Leishmaniasis, Visceral - immunology; Leishmaniasis, Visceral - parasitology; Leishmaniasis, Visceral - prevention & control; Mice; Mice, Inbred BALB C; niosomes; nucleotide sequences; people; Recombinant Proteins - genetics; Recombinant Proteins - immunology; recombinant vaccines; Vaccination; Vaccine; Vaccines, DNA; Vaccines, Subunit
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2011.12.067

Highlights ► L. donovani gamma-glutamyl cysteine synthetase (γGCS) DNA and protein vaccine to cross protect against L. major and L. mexicana determined. ► Protein vaccine was better than the DNA vaccine. ► Only partial protection obtained. ► L. donovani γGCS could be used in a cocktail vaccine against all 3 species.