Intracardiac Thrombosis and Acute Myocardial Infarction as Initial Presentation of Antiphospholipid Syndrome

Abstract Antiphospholipid syndrome is a disorder characterized by arterial or venous thrombosis, high plasma levels of antiphospholipid antibodies, recurrent fetal loss (in women) and thrombocytopenia. The authors present a case of a 28-year-old man with no significant medical history who presented...

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Bibliographic Details
Published in:The American journal of the medical sciences 2011-09, Vol.342 (3), p.254-256
Main Authors: Sharma, Ajay K., MD, Baig, M. Wajid, MD, Heist, E. Kevin, MD, PhD
Format: Article
Language:English
Subjects:
Acute Disease
Acute myocardial infarction
Adult
Antibodies, Antiphospholipid - immunology
Antiphospholipid syndrome
Antiphospholipid Syndrome - complications
Antiphospholipid Syndrome - diagnosis
Antiphospholipid Syndrome - immunology
Biological and medical sciences
Cardiology. Vascular system
Coronary heart disease
Coronary Thrombosis - etiology
General aspects
Heart
Humans
Immunopathology
Internal Medicine
Intracardiac thrombosis
Male
Medical sciences
Myocardial Infarction - etiology
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Summary:Abstract Antiphospholipid syndrome is a disorder characterized by arterial or venous thrombosis, high plasma levels of antiphospholipid antibodies, recurrent fetal loss (in women) and thrombocytopenia. The authors present a case of a 28-year-old man with no significant medical history who presented with ST elevation myocardial infarction (MI) and underwent percutaneous intervention to left anterior descending artery. He was also found to have intracardiac thrombosis, thrombocytopenia, elevated activated partial thromboplastin time and persistently elevated anticardiolipin and beta-2 glycoprotein antibodies. The authors performed a literature search regarding the frequency of MI and intracardiac thrombosis as the primary presentation of antiphospholipid syndrome and the relationship of antiphospholipid antibodies with MI.
ISSN:0002-9629
1538-2990
DOI:10.1097/MAJ.0b013e3182267a7b