Similar cytogenetic findings in two synchronous secondary peripheral chondrosarcomas in a patient with multiple osteochondromas

Secondary peripheral chondrosarcoma is a malignant chondroid tumor arising in a benign precursor, either an osteochondroma or an enchondroma. Multiple osteochondromas syndrome (MO) is an autosomal dominant skeletal disorder associated with bony growths in the form of osteochondromas that occasionall...

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Bibliographic Details
Published in:Cancer genetics 2011-12, Vol.204 (12), p.677-681
Main Authors: Kyriazoglou, Anastasios I, Dimitriadis, Efthimios, Arnogiannaki, Niki, Brandal, Petter, Heim, Sverre, Pandis, Nikos
Format: Article
Language:English
Subjects:
Benign
Cell Transformation, Neoplastic - genetics
Chondrosarcoma - genetics
Chondrosarcoma - secondary
Chromosome Aberrations
Chromosome Banding
Comparative Genomic Hybridization
DNA Mutational Analysis
Exostoses, Multiple Hereditary - genetics
Exostoses, Multiple Hereditary - pathology
EXT1
EXT2
Hematology, Oncology and Palliative Medicine
Humans
Karyotype
Male
Medical Education
Middle Aged
multiple osteochondromas syndrome
N-Acetylglucosaminyltransferases - genetics
osteochondroma
Secondary peripheral chondrosarcoma
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Summary:Secondary peripheral chondrosarcoma is a malignant chondroid tumor arising in a benign precursor, either an osteochondroma or an enchondroma. Multiple osteochondromas syndrome (MO) is an autosomal dominant skeletal disorder associated with bony growths in the form of osteochondromas that occasionally undergo malignant transformation to secondary peripheral chondrosarcomas. We describe the genetic examination of three secondary peripheral chondrosarcomas that had arisen synchronously from osteochondromas in a patient with MO by chromosome banding, high resolution chromosomal comparative genomic hybridization, and mutation analysis of the EXT1 and EXT2 genes. In two of the tumors (the third was not genetically informative), very similar chromosome abnormalities were found, indicating that they must somehow be part of the same neoplastic process in spite of being anatomically distinct.
ISSN:2210-7762
2210-7770
DOI:10.1016/j.cancergen.2011.10.013