NT-proBNP levels in patients with non-ST-segment elevation acute coronary syndrome

Non-ST-segment elevation acute coronary syndrome is associated with elevation of brain natriuretic peptide and markers of myocardial necrosis, although its relationship with the TIMI score and left ventricular function are largely unknown. To evaluate the correlation between plasma N-terminal pro-br...

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Bibliographic Details
Published in:Arquivos brasileiros de cardiologia 2011-12, Vol.97 (6), p.456-461
Main Authors: Castro, Luiz Ricardo A, Alencar, Maria Clara N, Barbosa, Márcia M, Nunes, Maria do Carmo P, Cardoso, José Ronaldo, Ribeiro, Antonio Luiz P
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - physiopathology
Biomarkers - blood
Creatine Kinase, MB Form - blood
Epidemiologic Methods
Female
Humans
Male
Middle Aged
Myocardium - pathology
Natriuretic Peptide, Brain - blood
Necrosis
Peptide Fragments - blood
Risk Assessment
Stroke Volume - physiology
Troponin I - blood
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Summary:Non-ST-segment elevation acute coronary syndrome is associated with elevation of brain natriuretic peptide and markers of myocardial necrosis, although its relationship with the TIMI score and left ventricular function are largely unknown. To evaluate the correlation between plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and markers of myocardial necrosis [creatine phosphokinase muscle-brain fraction (CK-MB) and troponin I], TIMI risk score and left ventricular ejection fraction in patients with non-ST-segment elevation acute coronary syndrome. Eighty-seven patients with non-ST-segment elevation acute coronary syndrome were divided into two groups: 37 (42.5%) with unstable angina and 50 (57.5%) with non-ST-segment elevation myocardial infarction. Left ventricular ejection fraction more than 40% was found in 86.2% of the total sample. Serum levels of NT-proBNP was higher in patients with non-ST elevation myocardial infarction than in those with unstable angina (p
ISSN:1678-4170
DOI:10.1590/S0066-782X2011005000114