Unusual Isomeric Corniculatolides from Mangrove, Aegiceras corniculatum

Four new isomeric macrolides of combretastatin D-2 congeners named isocorniculatolide A (1), 11-O-methylisocorniculatolide A (2), 11-O-methylcorniculatolide A (3), and 12-hydroxy-11-O-methylcorniculatolide A (4), and the known corniculatolide A (5), arjunolic acid, and maslinic acid were isolated fr...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2012-02, Vol.75 (2), p.275-279
Main Authors: Ponnapalli, M. Gowri, Annam, S. CH. V. A. Rao, Ravirala, Saidulu, Sukki, Sushma, Ankireddy, Madhu, Tuniki, V. Raju
Format: Article
Language:English
Subjects:
Bibenzyls - chemistry
Bibenzyls - isolation & purification
Crystallography, X-Ray
India
Macrolides - chemistry
Macrolides - isolation & purification
Molecular Conformation
Molecular Structure
Myrsinaceae - chemistry
Nuclear Magnetic Resonance, Biomolecular
Plant Bark - chemistry
Stereoisomerism
Triterpenes - chemistry
Triterpenes - isolation & purification
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Summary:Four new isomeric macrolides of combretastatin D-2 congeners named isocorniculatolide A (1), 11-O-methylisocorniculatolide A (2), 11-O-methylcorniculatolide A (3), and 12-hydroxy-11-O-methylcorniculatolide A (4), and the known corniculatolide A (5), arjunolic acid, and maslinic acid were isolated from the CHCl3 extract of the bark of Aegiceras corniculatum. The structures of the new compounds (1–4) were elucidated by a combination of spectroscopic analysis (1–5), chemical modifications, and single-crystal X-ray analysis (1).
ISSN:0163-3864
1520-6025
DOI:10.1021/np200789s