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Hepatitis B virus among maintainence haemodialysis patients: A report from Karachi, Pakistan
To study the characterstics, pattern of viral markers, hepatic transaminases and other associated hepatitis virus infections among maintainence haemodialysis patients. This prospective cross-sectional study was conducted at the dialysis unit of Sindh Institute of Urology and Transplantation Karachi...
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| Published in: | Journal of the Pakistan Medical Association 2011-12, Vol.61 (12), p.1210-1214 |
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| container_title | Journal of the Pakistan Medical Association |
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| creator | KHALID IDREES, Muhammad BATOOL, Salma AHMED, Ejaz |
| description | To study the characterstics, pattern of viral markers, hepatic transaminases and other associated hepatitis virus infections among maintainence haemodialysis patients.
This prospective cross-sectional study was conducted at the dialysis unit of Sindh Institute of Urology and Transplantation Karachi on end-stage renal disease (ESRD) patients undergoing maintainence haemodialysis from November 2009 to April 2010. Patients on anti-viral drugs were excluded Blood samples were taken, immediately before start of dialysis, for Hepatitis B virus serology, anti-HCV, polymerase chain reaction (PCR) for HBV DNA and biochemical tests. Abdominal ultrasound was performed for liver, spleen, portal vein diameter and presence or absence of ascites. Data analysis was done by using SPSS 10.0. The level of significance was taken as 0.05.
Out of 1220 ESRD patients on maintainence haemodialysis at SIUT, 124 were HBsAg positive but 26 patients were excluded as they had received anti-viral therapy. Finally 98 patients including 71 (72%) males and 27 (28%) females completed the study. The mean age was 34.98 +/- 12.67 years. Most of the patients did not have hepatitis symptoms. ALT level was raised above cutoff value of 20 IU/ml in 62.2% patients while AST was raised in 75.4% patients. HBeAg was positive in 34.6%, anti-HBe antibody was positive in 65% patients and HBV DNA was detected in 65.3%. More than half of the patients had HCV co-infection. Six patients had cirrhosis. Thirty four patients were non-replicating carriers. The mean duration of dialysis and duration of HBsAg positivity were significantly longer in those patients who had hepatitis B and hepatitis C coinfection (p |
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This prospective cross-sectional study was conducted at the dialysis unit of Sindh Institute of Urology and Transplantation Karachi on end-stage renal disease (ESRD) patients undergoing maintainence haemodialysis from November 2009 to April 2010. Patients on anti-viral drugs were excluded Blood samples were taken, immediately before start of dialysis, for Hepatitis B virus serology, anti-HCV, polymerase chain reaction (PCR) for HBV DNA and biochemical tests. Abdominal ultrasound was performed for liver, spleen, portal vein diameter and presence or absence of ascites. Data analysis was done by using SPSS 10.0. The level of significance was taken as 0.05.
Out of 1220 ESRD patients on maintainence haemodialysis at SIUT, 124 were HBsAg positive but 26 patients were excluded as they had received anti-viral therapy. Finally 98 patients including 71 (72%) males and 27 (28%) females completed the study. The mean age was 34.98 +/- 12.67 years. Most of the patients did not have hepatitis symptoms. ALT level was raised above cutoff value of 20 IU/ml in 62.2% patients while AST was raised in 75.4% patients. HBeAg was positive in 34.6%, anti-HBe antibody was positive in 65% patients and HBV DNA was detected in 65.3%. More than half of the patients had HCV co-infection. Six patients had cirrhosis. Thirty four patients were non-replicating carriers. The mean duration of dialysis and duration of HBsAg positivity were significantly longer in those patients who had hepatitis B and hepatitis C coinfection (p<0.05).
Hepatitis B virus infection in dialysis dependent patients is mostly asymptomatic. Mild transaminase elevation is frequently encountered.</description><identifier>ISSN: 0030-9982</identifier><identifier>PMID: 22355969</identifier><identifier>CODEN: JJPAD4</identifier><language>eng</language><publisher>Karachi: Pakistan Medical Association</publisher><subject>Adult ; Alanine Transaminase - blood ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antiviral agents ; Biological and medical sciences ; Chronic kidney failure ; Cross-Sectional Studies ; Development and progression ; Emergency and intensive care: renal failure. Dialysis management ; Female ; General aspects ; Health aspects ; Hepatitis B ; Hepatitis B - blood ; Hepatitis B - diagnosis ; Hepatitis B Surface Antigens - blood ; Hepatitis B virus ; Hepatitis B virus - immunology ; Human viral diseases ; Humans ; Infection ; Infectious diseases ; Intensive care medicine ; Kidney diseases ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - therapy ; Male ; Medical research ; Medical sciences ; Medicine, Experimental ; Middle Aged ; Pakistan ; Prospective Studies ; Renal Dialysis ; Viral diseases ; Viral hepatitis ; Virus diseases ; Young Adult</subject><ispartof>Journal of the Pakistan Medical Association, 2011-12, Vol.61 (12), p.1210-1214</ispartof><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Knowledge Bylanes</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25428766$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22355969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KHALID IDREES, Muhammad</creatorcontrib><creatorcontrib>BATOOL, Salma</creatorcontrib><creatorcontrib>AHMED, Ejaz</creatorcontrib><title>Hepatitis B virus among maintainence haemodialysis patients: A report from Karachi, Pakistan</title><title>Journal of the Pakistan Medical Association</title><addtitle>J Pak Med Assoc</addtitle><description>To study the characterstics, pattern of viral markers, hepatic transaminases and other associated hepatitis virus infections among maintainence haemodialysis patients.
This prospective cross-sectional study was conducted at the dialysis unit of Sindh Institute of Urology and Transplantation Karachi on end-stage renal disease (ESRD) patients undergoing maintainence haemodialysis from November 2009 to April 2010. Patients on anti-viral drugs were excluded Blood samples were taken, immediately before start of dialysis, for Hepatitis B virus serology, anti-HCV, polymerase chain reaction (PCR) for HBV DNA and biochemical tests. Abdominal ultrasound was performed for liver, spleen, portal vein diameter and presence or absence of ascites. Data analysis was done by using SPSS 10.0. The level of significance was taken as 0.05.
Out of 1220 ESRD patients on maintainence haemodialysis at SIUT, 124 were HBsAg positive but 26 patients were excluded as they had received anti-viral therapy. Finally 98 patients including 71 (72%) males and 27 (28%) females completed the study. The mean age was 34.98 +/- 12.67 years. Most of the patients did not have hepatitis symptoms. ALT level was raised above cutoff value of 20 IU/ml in 62.2% patients while AST was raised in 75.4% patients. HBeAg was positive in 34.6%, anti-HBe antibody was positive in 65% patients and HBV DNA was detected in 65.3%. More than half of the patients had HCV co-infection. Six patients had cirrhosis. Thirty four patients were non-replicating carriers. The mean duration of dialysis and duration of HBsAg positivity were significantly longer in those patients who had hepatitis B and hepatitis C coinfection (p<0.05).
Hepatitis B virus infection in dialysis dependent patients is mostly asymptomatic. Mild transaminase elevation is frequently encountered.</description><subject>Adult</subject><subject>Alanine Transaminase - blood</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Chronic kidney failure</subject><subject>Cross-Sectional Studies</subject><subject>Development and progression</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>General aspects</subject><subject>Health aspects</subject><subject>Hepatitis B</subject><subject>Hepatitis B - blood</subject><subject>Hepatitis B - diagnosis</subject><subject>Hepatitis B Surface Antigens - blood</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - immunology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infection</subject><subject>Infectious diseases</subject><subject>Intensive care medicine</subject><subject>Kidney diseases</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Pakistan</subject><subject>Prospective Studies</subject><subject>Renal Dialysis</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Virus diseases</subject><subject>Young Adult</subject><issn>0030-9982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNpF0D1PwzAQBuAMIFoKfwF5ARYiuefEjtkKAoqoBANsSNHFuTSGfBTbQeq_J6hFDKdbnnul9w6iKeeCx1pnMImOvf_gHGTK-VE0ARBpqqWeRu9L2mCwwXp2w76tGzzDtu_WrEXbhXGoM8RqpLYvLTZbP8LfA-qCv2YL5mjTu8Aq17fsCR2a2l6xF_y0PmB3Eh1W2Hg63e9Z9HZ_93q7jFfPD4-3i1W8BjUPcWFK0BUAkMmEqrRMlFHKVDLRWAgjQQMvBWUlVAUkY4O5KjMpOBBKTqIQs-hyl7tx_ddAPuSt9YaaBjvqB5_rsa7KeCJGebGTa2worwmbUPu-GYLtO58vIEtS4DxTIzzbRw5FS2W-cbZFt83_PjeC8z1Ab7CpHHbG-n-XJpApKcUPNQt1ZQ</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>KHALID IDREES, Muhammad</creator><creator>BATOOL, Salma</creator><creator>AHMED, Ejaz</creator><general>Pakistan Medical Association</general><general>Knowledge Bylanes</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Hepatitis B virus among maintainence haemodialysis patients: A report from Karachi, Pakistan</title><author>KHALID IDREES, Muhammad ; BATOOL, Salma ; AHMED, Ejaz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g271t-bcd29f222ec837f9647c77cf649ab3c62920d3e8d2fb2450017d86302ea60e3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Alanine Transaminase - blood</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Chronic kidney failure</topic><topic>Cross-Sectional Studies</topic><topic>Development and progression</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>General aspects</topic><topic>Health aspects</topic><topic>Hepatitis B</topic><topic>Hepatitis B - blood</topic><topic>Hepatitis B - diagnosis</topic><topic>Hepatitis B Surface Antigens - blood</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - immunology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infection</topic><topic>Infectious diseases</topic><topic>Intensive care medicine</topic><topic>Kidney diseases</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Pakistan</topic><topic>Prospective Studies</topic><topic>Renal Dialysis</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Virus diseases</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>KHALID IDREES, Muhammad</creatorcontrib><creatorcontrib>BATOOL, Salma</creatorcontrib><creatorcontrib>AHMED, Ejaz</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Pakistan Medical Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KHALID IDREES, Muhammad</au><au>BATOOL, Salma</au><au>AHMED, Ejaz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis B virus among maintainence haemodialysis patients: A report from Karachi, Pakistan</atitle><jtitle>Journal of the Pakistan Medical Association</jtitle><addtitle>J Pak Med Assoc</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>61</volume><issue>12</issue><spage>1210</spage><epage>1214</epage><pages>1210-1214</pages><issn>0030-9982</issn><coden>JJPAD4</coden><abstract>To study the characterstics, pattern of viral markers, hepatic transaminases and other associated hepatitis virus infections among maintainence haemodialysis patients.
This prospective cross-sectional study was conducted at the dialysis unit of Sindh Institute of Urology and Transplantation Karachi on end-stage renal disease (ESRD) patients undergoing maintainence haemodialysis from November 2009 to April 2010. Patients on anti-viral drugs were excluded Blood samples were taken, immediately before start of dialysis, for Hepatitis B virus serology, anti-HCV, polymerase chain reaction (PCR) for HBV DNA and biochemical tests. Abdominal ultrasound was performed for liver, spleen, portal vein diameter and presence or absence of ascites. Data analysis was done by using SPSS 10.0. The level of significance was taken as 0.05.
Out of 1220 ESRD patients on maintainence haemodialysis at SIUT, 124 were HBsAg positive but 26 patients were excluded as they had received anti-viral therapy. Finally 98 patients including 71 (72%) males and 27 (28%) females completed the study. The mean age was 34.98 +/- 12.67 years. Most of the patients did not have hepatitis symptoms. ALT level was raised above cutoff value of 20 IU/ml in 62.2% patients while AST was raised in 75.4% patients. HBeAg was positive in 34.6%, anti-HBe antibody was positive in 65% patients and HBV DNA was detected in 65.3%. More than half of the patients had HCV co-infection. Six patients had cirrhosis. Thirty four patients were non-replicating carriers. The mean duration of dialysis and duration of HBsAg positivity were significantly longer in those patients who had hepatitis B and hepatitis C coinfection (p<0.05).
Hepatitis B virus infection in dialysis dependent patients is mostly asymptomatic. Mild transaminase elevation is frequently encountered.</abstract><cop>Karachi</cop><pub>Pakistan Medical Association</pub><pmid>22355969</pmid><tpages>5</tpages></addata></record> |
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| source | Open Access: DOAJ - Directory of Open Access Journals |
| subjects | Adult Alanine Transaminase - blood Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antiviral agents Biological and medical sciences Chronic kidney failure Cross-Sectional Studies Development and progression Emergency and intensive care: renal failure. Dialysis management Female General aspects Health aspects Hepatitis B Hepatitis B - blood Hepatitis B - diagnosis Hepatitis B Surface Antigens - blood Hepatitis B virus Hepatitis B virus - immunology Human viral diseases Humans Infection Infectious diseases Intensive care medicine Kidney diseases Kidney Failure, Chronic - complications Kidney Failure, Chronic - therapy Male Medical research Medical sciences Medicine, Experimental Middle Aged Pakistan Prospective Studies Renal Dialysis Viral diseases Viral hepatitis Virus diseases Young Adult |
| title | Hepatitis B virus among maintainence haemodialysis patients: A report from Karachi, Pakistan |
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