Magnesium, a drug of diverse use

Magnesium has evolved as a drug with diverse clinical applications. Mg++ is an important caution and its homeostasis is very important for normal body functioning. The physiological role of Mg is due to its calcium channel blocking properties at smooth muscle, skeletal muscle and conduction system l...

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Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2011-12, Vol.61 (12), p.1220-1225
Main Authors: IRFAN AKHTAR, Mohammad, ULLAH, Hameed, HAMID, Mohammad
Format: Article
Language:English
Subjects:
Analgesics
Biological and medical sciences
Calcium Channel Blockers - therapeutic use
Calcium channels
Cost-Benefit Analysis
Evidence-Based Medicine
General aspects
Heart beat
Humans
Hypercalciuria - complications
Magnesium - physiology
Magnesium - therapeutic use
Medical sciences
Methyl aspartate
Nephrocalcinosis - complications
Physiological aspects
Renal Tubular Transport, Inborn Errors - complications
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Summary:Magnesium has evolved as a drug with diverse clinical applications. Mg++ is an important caution and its homeostasis is very important for normal body functioning. The physiological role of Mg is due to its calcium channel blocking properties at smooth muscle, skeletal muscle and conduction system levels. The analgesic properties are due to NMDA receptor blocking action. Mg++ is beneficial in acute Myocardial Infarction, protection during open heart surgery and treatment and prevention of heart rhythm disturbances. Mg has an established role in the management of preeclampsia and eclampsia. Magnesium prevents or controls convulsions by blocking neuromuscular transmission and decreasing the release of acetylcholine at the motor nerve terminals. The use of MgSO4 in treating tetanus and acute asthma is established. In conclusion, Mg is a cost effective, widely used drug with multidisciplinary applications. Its majority of physiological effects are attributed to calcium channel blocking properties.
ISSN:0030-9982