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Antibody persistence for 3 years following two doses of tetravalent measles–mumps–rubella–varicella vaccine in healthy children

Two doses of a varicella-containing vaccine in healthy children

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Published in:European journal of pediatrics 2012-03, Vol.171 (3), p.463-470
Main Authors: Knuf, Markus, Zepp, Fred, Helm, Klaus, Maurer, Hartwig, Prieler, Albrecht, Kieninger-Baum, Dorothee, Douha, Martine, Willems, Paul
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container_title European journal of pediatrics
container_volume 171
creator Knuf, Markus
Zepp, Fred
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description Two doses of a varicella-containing vaccine in healthy children
doi_str_mv 10.1007/s00431-011-1569-4
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Persistence of immunity against measles, mumps, rubella, and varicella as well as varicella breakthrough cases were assessed 3 years after two-dose measles, mumps, rubella, and varicella (MMRV) vaccination or concomitant MMR (Priorix™) and varicella (Varilrix™) vaccination. Four hundred ninety-four healthy children, 12–18 months old at the time of the first dose, received either two doses of MMRV vaccine (GlaxoSmithKline Biologicals) 42–56 days apart (MMRV, N  = 371) or one dose of MMR and varicella vaccines administered simultaneously at separate sites, followed by another MMR vaccination 42–56 days later (MMR + V, N  = 123). Three hundred-four subjects participated in 3-year follow-up for persistence of immunity and occurrence of breakthrough varicella (MMRV, N  = 225; MMR + V, N  = 79). Antibodies were measured by ELISA (measles, mumps, rubella) and immunofluorescence (varicella). Contacts with individuals with varicella or zoster and cases of breakthrough varicella disease were recorded. Three years post-vaccination seropositivity rates in subjects seronegative before vaccination were: MMRV-measles, 98.5% (geometric mean titer [GMT] = 3,599.6); mumps, 97.4% (GMT = 1,754.5); rubella, 100% (GMT = 51.9); varicella, 99.4% (GMT = 225.5); MMR + V-measles, 97.0% (GMT = 1,818.8); mumps, 93.8% (GMT = 1,454.6); rubella, 100% (GMT = 53.8); and varicella, 96.8% (GMT = 105.8). Of the subjects, 15–20% reported contact with individuals with varicella/zoster each year. After 3 years, the cumulative varicella breakthrough disease rate was 0.7% (two cases) in the MMRV group and 5.4% (five cases) in the MMR + V group. Conclusion : Immunogenicity of the combined MMRV vaccine was sustained 3 years post-vaccination. 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Persistence of immunity against measles, mumps, rubella, and varicella as well as varicella breakthrough cases were assessed 3 years after two-dose measles, mumps, rubella, and varicella (MMRV) vaccination or concomitant MMR (Priorix™) and varicella (Varilrix™) vaccination. Four hundred ninety-four healthy children, 12–18 months old at the time of the first dose, received either two doses of MMRV vaccine (GlaxoSmithKline Biologicals) 42–56 days apart (MMRV, N  = 371) or one dose of MMR and varicella vaccines administered simultaneously at separate sites, followed by another MMR vaccination 42–56 days later (MMR + V, N  = 123). Three hundred-four subjects participated in 3-year follow-up for persistence of immunity and occurrence of breakthrough varicella (MMRV, N  = 225; MMR + V, N  = 79). Antibodies were measured by ELISA (measles, mumps, rubella) and immunofluorescence (varicella). Contacts with individuals with varicella or zoster and cases of breakthrough varicella disease were recorded. Three years post-vaccination seropositivity rates in subjects seronegative before vaccination were: MMRV-measles, 98.5% (geometric mean titer [GMT] = 3,599.6); mumps, 97.4% (GMT = 1,754.5); rubella, 100% (GMT = 51.9); varicella, 99.4% (GMT = 225.5); MMR + V-measles, 97.0% (GMT = 1,818.8); mumps, 93.8% (GMT = 1,454.6); rubella, 100% (GMT = 53.8); and varicella, 96.8% (GMT = 105.8). Of the subjects, 15–20% reported contact with individuals with varicella/zoster each year. After 3 years, the cumulative varicella breakthrough disease rate was 0.7% (two cases) in the MMRV group and 5.4% (five cases) in the MMR + V group. Conclusion : Immunogenicity of the combined MMRV vaccine was sustained 3 years post-vaccination. (208136/041/NCT00406211).</description><subject>Antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Chicken pox</subject><subject>Chickenpox - immunology</subject><subject>Chickenpox Vaccine - administration &amp; dosage</subject><subject>Chickenpox Vaccine - immunology</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Combined vaccines</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Herpesvirus 3, Human - immunology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunization Schedule</subject><subject>Immunofluorescence</subject><subject>Immunogenicity</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Measles</subject><subject>Measles - immunology</subject><subject>Measles virus - immunology</subject><subject>Measles-Mumps-Rubella Vaccine - administration &amp; dosage</subject><subject>Measles-Mumps-Rubella Vaccine - immunology</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Mumps</subject><subject>Mumps - immunology</subject><subject>Mumps virus - immunology</subject><subject>Original Paper</subject><subject>Pediatrics</subject><subject>Rubella</subject><subject>Rubella - immunology</subject><subject>Rubella virus - immunology</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Vaccines, Combined</subject><subject>Varicella</subject><subject>Viral diseases</subject><subject>Viral diseases of the respiratory system and ent viral diseases</subject><subject>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><issn>0340-6199</issn><issn>1432-1076</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kU1uFDEQhS1ERIbAAdggSwjBpsFu_7WXUcRPpEhsYN1yu6szjtz2YHdPNLusuAAX4CwchZPgzkwAIcGqyvL3XpX9EHpCyStKiHqdCeGMVoTSigqpK34PrShndUWJkvfRijBOKkm1PkYPc74iRaNp8wAd11QzIRq-Ql9Ow-S62O_wBlJ2eYJgAQ8xYfb92w5MyuXgfbx24RJP1xH3MUPGccATTMlsjYcw4RFM9pB_3Hwd53Gz1DR34L0p3dYkZ5ceb421LgB2Aa_B-Gm9w3btfJ8gPEJHg_EZHh_qCfr09s3Hs_fVxYd352enF5XljE-VZQpkTTQXomtoowCEYT0njbBKQq9VryyVYATUSja2E13PuqF8kuK2loqwE_Ri77tJ8fMMeWpHl2-3CxDn3OqaCaUl0YV8-V-S0lrUTDG6mD77C72KcwrlHS0lWggtG80LRfeUTTHnBEO7SW40aVegdomz3cfZljjbJc520Tw9OM_dCP0vxV1-BXh-AEy2xg_JBOvyb65AuuGicPWey-UqXEL6c8V_Tf8JgIy8gg</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Knuf, Markus</creator><creator>Zepp, Fred</creator><creator>Helm, Klaus</creator><creator>Maurer, Hartwig</creator><creator>Prieler, Albrecht</creator><creator>Kieninger-Baum, Dorothee</creator><creator>Douha, Martine</creator><creator>Willems, Paul</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Antibody persistence for 3 years following two doses of tetravalent measles–mumps–rubella–varicella vaccine in healthy children</title><author>Knuf, Markus ; 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Persistence of immunity against measles, mumps, rubella, and varicella as well as varicella breakthrough cases were assessed 3 years after two-dose measles, mumps, rubella, and varicella (MMRV) vaccination or concomitant MMR (Priorix™) and varicella (Varilrix™) vaccination. Four hundred ninety-four healthy children, 12–18 months old at the time of the first dose, received either two doses of MMRV vaccine (GlaxoSmithKline Biologicals) 42–56 days apart (MMRV, N  = 371) or one dose of MMR and varicella vaccines administered simultaneously at separate sites, followed by another MMR vaccination 42–56 days later (MMR + V, N  = 123). Three hundred-four subjects participated in 3-year follow-up for persistence of immunity and occurrence of breakthrough varicella (MMRV, N  = 225; MMR + V, N  = 79). Antibodies were measured by ELISA (measles, mumps, rubella) and immunofluorescence (varicella). Contacts with individuals with varicella or zoster and cases of breakthrough varicella disease were recorded. Three years post-vaccination seropositivity rates in subjects seronegative before vaccination were: MMRV-measles, 98.5% (geometric mean titer [GMT] = 3,599.6); mumps, 97.4% (GMT = 1,754.5); rubella, 100% (GMT = 51.9); varicella, 99.4% (GMT = 225.5); MMR + V-measles, 97.0% (GMT = 1,818.8); mumps, 93.8% (GMT = 1,454.6); rubella, 100% (GMT = 53.8); and varicella, 96.8% (GMT = 105.8). Of the subjects, 15–20% reported contact with individuals with varicella/zoster each year. After 3 years, the cumulative varicella breakthrough disease rate was 0.7% (two cases) in the MMRV group and 5.4% (five cases) in the MMR + V group. Conclusion : Immunogenicity of the combined MMRV vaccine was sustained 3 years post-vaccination. (208136/041/NCT00406211).</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21935584</pmid><doi>10.1007/s00431-011-1569-4</doi><tpages>8</tpages></addata></record>
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language eng
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source Springer Nature
subjects Antibodies
Antibodies, Viral - blood
Biological and medical sciences
Chicken pox
Chickenpox - immunology
Chickenpox Vaccine - administration & dosage
Chickenpox Vaccine - immunology
Child, Preschool
Children
Combined vaccines
Enzyme-Linked Immunosorbent Assay
Fluorescent Antibody Technique, Indirect
Follow-Up Studies
General aspects
Herpesvirus 3, Human - immunology
Human viral diseases
Humans
Immunity
Immunization Schedule
Immunofluorescence
Immunogenicity
Infant
Infectious diseases
Measles
Measles - immunology
Measles virus - immunology
Measles-Mumps-Rubella Vaccine - administration & dosage
Measles-Mumps-Rubella Vaccine - immunology
Medical sciences
Medicine
Medicine & Public Health
Mumps
Mumps - immunology
Mumps virus - immunology
Original Paper
Pediatrics
Rubella
Rubella - immunology
Rubella virus - immunology
Vaccination
Vaccines
Vaccines, Combined
Varicella
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
title Antibody persistence for 3 years following two doses of tetravalent measles–mumps–rubella–varicella vaccine in healthy children
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