Coagulation abnormalities in deceased donors are associated with unsuccessful human islet cell isolation

Abstract An equivalent islet number (EIN) greater than 300,000 is necessary for islet cell transplantation for a recipient who weighs about 60 kg. The aim of this study is to identify factors that affect isolation outcome. The most significant independent predictor for successful islet isolation fro...

Full description

Saved in:
Bibliographic Details
Published in:Diabetes research and clinical practice 2012-03, Vol.95 (3), p.e45-e48
Main Authors: Kim, Jong Man, Jin, Sang Man, Oh, Seung Hoon, Lee, Han-Sin, Kim, Jae Hyeon, Kwon, Choon Hyuck David, Kim, Sung Joo, Joh, Jae-Won, Kim, Kwang Won
Format: Article
Language:English
Subjects:
Blood Coagulation Disorders
Cadaver
Cell Count
Coagulation
Endocrinology & Metabolism
Humans
Inflammation
International Normalized Ratio
International normalized ratio (INR)
Islet isolation
Islets of Langerhans - pathology
Islets of Langerhans Transplantation - standards
Tissue Donors
Treatment Failure
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract An equivalent islet number (EIN) greater than 300,000 is necessary for islet cell transplantation for a recipient who weighs about 60 kg. The aim of this study is to identify factors that affect isolation outcome. The most significant independent predictor for successful islet isolation from deceased donors was low international normalized ratio (INR).
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2011.10.044