Multilocus sequence types of invasive Corynebacterium diphtheriae isolated in the Rio de Janeiro urban area, Brazil

Invasive infections caused by Corynebacterium diphtheriae in vaccinated and non-vaccinated individuals have been reported increasingly. In this study we used multilocus sequence typing (MLST) to study genetic relationships between six invasive strains of this bacterium isolated solely in the urban a...

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Bibliographic Details
Published in:Epidemiology and infection 2012-04, Vol.140 (4), p.617-620
Main Authors: VIGUETTI, S. Z., PACHECO, L. G. C., SANTOS, L. S., SOARES, S. C., BOLT, F., BALDWIN, A., DOWSON, C. G., ROSSO, M. L., GUISO, N., MIYOSHI, A., HIRATA, R., MATTOS-GUARALDI, A. L., AZEVEDO, V.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Bacterial Typing Techniques
Bacteriology
Biological and medical sciences
Brazil - epidemiology
Child
Childhood infections
Cloning
Corynebacterium diphtheriae - genetics
Diphtheria
Diphtheria - epidemiology
Diphtheria - microbiology
Disease
Endocarditis
Female
Fundamental and applied biological sciences. Psychology
Genes
Genotype & phenotype
Humans
Infections
Male
Microbiology
Miscellaneous
Multilocus Sequence Typing
Sucrose
Urban areas
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Summary:Invasive infections caused by Corynebacterium diphtheriae in vaccinated and non-vaccinated individuals have been reported increasingly. In this study we used multilocus sequence typing (MLST) to study genetic relationships between six invasive strains of this bacterium isolated solely in the urban area of Rio de Janeiro, Brazil, during a 10-year period. Of note, all the strains rendered negative results in PCR reactions for the tox gene, and four strains presented an atypical sucrose-fermenting ability. Five strains represented new sequence types. MLST results did not support the hypothesis that invasive (sucrose-positive) strains of C. diphtheriae are part of a single clonal complex. Instead, one of the main findings of the study was that such strains can be normally found in clonal complexes with strains related to non-invasive disease. Comparative analyses with C. diphtheriae isolated in different countries provided further information on the geographical circulation of some sequence types.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268811000963