The role of leukocyte counts in patients with unstable angina pectoris or myocardial infarction; prognostic significance and correlation with plasma brain natriuretic peptide (bnp) levels

To study the role of leukocyte count in patients with unstable angina pectoris or myocardial infarction (Acute Coronary Syndrome) its prognostic significance and correlation with plasma brain natriuretic peptide (BNP) levels. A total of 143 Patients with unstable angina pectoris, non-ST segment elev...

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Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2011, Vol.61 (1), p.51-54
Main Authors: AKHTAR, Naveed, MALIK MUHAMMAD ADIL, AHMED, Waqas, HABIB-UR-REHMAN, MUMTAZ ALI SHAH
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Angina, Unstable - blood
Angina, Unstable - mortality
Biological and medical sciences
Biomarkers - blood
Cardiology. Vascular system
Coronary heart disease
Female
General aspects
Heart
Humans
Incidence
Leukocyte Count
Male
Medical sciences
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - mortality
Myocarditis. Cardiomyopathies
Natriuretic Peptide, Brain - blood
Pakistan - epidemiology
Prognosis
Prospective Studies
Recurrence
Risk Factors
Smoking - adverse effects
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Summary:To study the role of leukocyte count in patients with unstable angina pectoris or myocardial infarction (Acute Coronary Syndrome) its prognostic significance and correlation with plasma brain natriuretic peptide (BNP) levels. A total of 143 Patients with unstable angina pectoris, non-ST segment elevation MI and ST segment elevation MI were considered for entry into the study. Plasma BNP levels were measured using a commercial BNP kit (AxSym System BNP Reagent Pack, Abbott Laboratories, Abbott Park, IL, USA). Leukocyte count was measured on CELL DYNE counter of Abbott Laboratories. Mean age of the patients were 58.67 +/- 12.48 years. Mean leukocyte count was 9772 +/- 3006 /cumm. In all 43 (30%) patients had high leukocyte count, and 82 (57%) patients had elevated BNP level. Out of 61 patients with normal BNP level, 49 (80%) had normal leukocyte count and 12 (20%) had elevated leukocyte count. Out of 82 patients with elevated BNP level, 51 (62%) had normal leukocyte count and 31 (38%) had elevated leukocyte count (P = 0.01). No statistically significant association was found between Leukocyte count and ACS. Although there is a trend of increased Leukocyte count noted in patients with increase BNP level. This finding necessitates further studies to elucidate its accurate significance.
ISSN:0030-9982