Native kidney BK virus nephropathy associated with chronic lymphocytic leukaemia

BK virus nephropathy (BKVN) is a well-recognized complication of renal transplantation. Several cases of native kidney BKVN following other solid organ or bone marrow transplants have been reported. We describe a patient with chronic lymphocytic leukaemia who presented with deteriorating renal funct...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2012-03, Vol.27 (3), p.1269-1271
Main Authors: MCCRORY, Richard, GRAY, Moyra, LEONARD, Niall, SMYTH, John, WOODMAN, Alastair
Format: Article
Language:English
Subjects:
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
BK Virus - genetics
BK Virus - isolation & purification
DNA, Viral - genetics
Emergency and intensive care: renal failure. Dialysis management
Human viral diseases
Humans
Immunosuppressive Agents - therapeutic use
Infectious diseases
Intensive care medicine
Isoxazoles - therapeutic use
Kidney Diseases - drug therapy
Kidney Diseases - etiology
Kidney Diseases - pathology
Leukemia, Lymphocytic, Chronic, B-Cell - complications
Male
Medical sciences
Polymerase Chain Reaction
Polyomavirus Infections - diagnosis
Polyomavirus Infections - drug therapy
Polyomavirus Infections - etiology
Prognosis
Tumor Virus Infections - diagnosis
Tumor Virus Infections - drug therapy
Tumor Virus Infections - etiology
Viral diseases
Viral hepatitis
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Description
Summary:BK virus nephropathy (BKVN) is a well-recognized complication of renal transplantation. Several cases of native kidney BKVN following other solid organ or bone marrow transplants have been reported. We describe a patient with chronic lymphocytic leukaemia who presented with deteriorating renal function with no history of solid organ or bone marrow transplantation. Renal biopsy demonstrated tubular injury characteristic of viral infection, confirmed as BK virus by immunohistochemistry and elevated serum BK viral titres. Treatment with leflunomide reduced serum viral titres and stabilized renal function. This is the first biopsy-proven case of native kidney BKVN in a patient with no previous transplantation history.
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfs002