Plasma Metabonomics as a Novel Diagnostic Approach for Major Depressive Disorder

Major depressive disorder (MDD) is a socially detrimental psychiatric disorder, contributing to increased healthcare expenditures and suicide rates. However, no empirical laboratory-based tests are available to support the diagnosis of MDD. In this study, a NMR-based plasma metabonomic method for th...

Full description

Saved in:
Bibliographic Details
Published in:Journal of proteome research 2012-03, Vol.11 (3), p.1741-1748
Main Authors: Zheng, Peng, Gao, Hong C, Li, Qi, Shao, Wei H, Zhang, Mei L, Cheng, Ke, Yang, De Y, Fan, Song H, Chen, Liang, Fang, Liang, Xie, Peng
Format: Article
Language:English
Subjects:
Acetates - blood
Adult
Amino Acids - blood
Biomarkers - blood
Case-Control Studies
Creatine - blood
Creatinine - blood
Depressive Disorder, Major - blood
Depressive Disorder, Major - diagnosis
Female
Humans
Inositol - blood
Lipoproteins - blood
Male
Metabolomics
Middle Aged
Sensitivity and Specificity
Statistics, Nonparametric
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Major depressive disorder (MDD) is a socially detrimental psychiatric disorder, contributing to increased healthcare expenditures and suicide rates. However, no empirical laboratory-based tests are available to support the diagnosis of MDD. In this study, a NMR-based plasma metabonomic method for the diagnosis of MDD was tested. Proton nuclear magnetic resonance (1H NMR) spectra of plasma sampled from first-episode drug-naı̈ve depressed patients (n = 58) and healthy controls (n = 42) were recorded and analyzed by orthogonal partial least-squares discriminant analysis (OPLS-DA). The OPLS-DA score plots of the spectra demonstrated that the depressed patient group was significantly distinguishable from the healthy control group. Moreover, the method accurately diagnosed blinded samples (n = 26) in an independent replication cohort with a sensitivity and specificity of 92.8% and 83.3%, respectively. Taken together, NMR-based plasma metabonomics may offer an accurate empirical laboratory-based method applicable to the diagnosis of MDD.
ISSN:1535-3893
1535-3907
DOI:10.1021/pr2010082