Characteristics of Diabetic Osteopenia in KK-Ay Diabetic Mice

We examined the bone mineral density (BMD) of the proximal region and the mid-diaphysis of the femur using dual energy X-ray absorption (DXA), the blood osteocalcin level and the blood glucose level every five weeks from 8 to 23 weeks old in KK-Ay diabetic mice. The BMD of the proximal region after...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2012/03/01, Vol.35(3), pp.438-443
Main Authors: Takagi, Satoshi, Miura, Toshihiro, Yamashita, Takenori, Ando, Naoki, Nakao, Haruka, Ishihara, Eriko, Ishida, Torao
Format: Article
Language:English
Subjects:
Animal models
Animals
Blood
Blood Glucose - analysis
Bone (cortical)
Bone (spongy)
Bone Density
Bone Diseases, Metabolic - blood
Bone Diseases, Metabolic - etiology
Bone Diseases, Metabolic - physiopathology
Bone mineral density
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Disease Models, Animal
Dual energy X-ray absorptiometry
Femur
Femur - physiopathology
Glucose
Ionizing radiation
KK-Ay mice
Male
Mice
Osteocalcin
Osteopenia
type 2 diabetes
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Summary:We examined the bone mineral density (BMD) of the proximal region and the mid-diaphysis of the femur using dual energy X-ray absorption (DXA), the blood osteocalcin level and the blood glucose level every five weeks from 8 to 23 weeks old in KK-Ay diabetic mice. The BMD of the proximal region after 18 weeks old was significantly lower when compared with that at 8 weeks old (p
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.35.438