Recent Advances in the Study on Resveratrol

Appropriate long-term drinking of red wine is associated with a reduced risk for lifestyle-related diseases such as cardiovascular disease and cancer, making resveratrol, a constituent of grapes and various other plants, an attractive compound to be studied. Historically, resveratrol has been identi...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2012/03/01, Vol.35(3), pp.273-279
Main Authors: Nakata, Rieko, Takahashi, Satoru, Inoue, Hiroyasu
Format: Article
Language:English
Subjects:
Animals
cyclooxygenase
Cyclooxygenase Inhibitors - pharmacology
endothelial nitric oxide synthase
Humans
Nitric Oxide Synthase Type III - metabolism
peroxisome proliferator-activated receptor
Peroxisome Proliferator-Activated Receptors - metabolism
Resveratrol
silent mating type information regulation 2 homolog 1
Sirtuin 1 - metabolism
Stilbenes - pharmacology
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Summary:Appropriate long-term drinking of red wine is associated with a reduced risk for lifestyle-related diseases such as cardiovascular disease and cancer, making resveratrol, a constituent of grapes and various other plants, an attractive compound to be studied. Historically, resveratrol has been identified as a phytoalexin, antioxidant, cyclooxygenase (COX) inhibitor, peroxisome proliferator-activated receptor (PPAR) activator, endothelial nitric oxide synthase (eNOS) inducer, silent mating type information regulation 2 homolog 1 (SIRT1) activator, and more. Despite scepticism concerning the biological availability of resveratrol, a growing body of in vivo evidence indicates that resveratrol has protective effects in several stress and disease models. Here, we provide a review of the studies on resveratrol, especially with respect to COX, PPAR, and eNOS activities, and discuss its potential for promoting human health.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.35.273