A theory-based approach to thermal field-flow fractionation of polyacrylates

A theory-based approach is presented for the development of thermal field-flow fractionation (ThFFF) of polyacrylates. The use of ThFFF for polymer analysis has been limited by an incomplete understanding of the thermal diffusion which plays an important role in retention and separation. Hence, a te...

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Bibliographic Details
Published in:Journal of Chromatography A 2011-09, Vol.1218 (39), p.7016-7022
Main Authors: Runyon, J. Ray, Williams, S. Kim Ratanathanawongs
Format: Article
Language:English
Subjects:
Acrylates
Analytical chemistry
Applied sciences
Chemistry
Chromatographic methods and physical methods associated with chromatography
chromatography
Exact sciences and technology
Feasibility
Fractionation
Mathematical analysis
Organic polymers
osmotic pressure
Other chromatographic methods
Physicochemistry of polymers
Polyacrylates
Polymer separations
Polystyrene resins
polystyrenes
Properties and characterization
Solvents
Soret coefficient
Structure, morphology and analysis
temperature
Thermal diffusion
Thermal field-flow fractionation
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Summary:A theory-based approach is presented for the development of thermal field-flow fractionation (ThFFF) of polyacrylates. The use of ThFFF for polymer analysis has been limited by an incomplete understanding of the thermal diffusion which plays an important role in retention and separation. Hence, a tedious trial-and-error approach to method development has been the normal practice when analyzing new materials. In this work, thermal diffusion theories based on temperature dependent osmotic pressure gradient and polymer–solvent interaction parameters were used to estimate thermal diffusion coefficients ( D T ) and retention times ( t r ) for different polymer–solvent pairs. These calculations identified methyl ethyl ketone as a solvent that would cause significant retention of poly( n-butyl acrylate) (PBA) and poly(methyl acrylate) (PMA). Experiments confirmed retention of these two polymers that have not been previously analyzed by ThFFF. Theoretical and experimental D T s and t r s for PBA, PMA, and polystyrene in different solvents agreed to within 20% and demonstrate the feasibility of this theory-based approach.
ISSN:0021-9673
DOI:10.1016/j.chroma.2011.08.007