Polyhydroxybutyrate (PHB) Scaffolds as a Model for Nerve Tissue Engineering Application: Fabrication and In Vitro Assay

In this study, we fabricated PHB scaffolds by solid/liquid phase separation method. The properties of fabricated scaffolds were investigated using SEM, DMTA, and DSC. Our studies noticed that for an approach to scaffolds that contain tubular morphology and better mechanical properties, the solution...

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Bibliographic Details
Published in:International journal of polymeric materials 2011-07, Vol.60 (8), p.562-575
Main Authors: Khorasani, M. T., Mirmohammadi, S. A., Irani, S.
Format: Article
Language:English
Subjects:
Applied sciences
Bioassays
Biological and medical sciences
Exact sciences and technology
Forms of application and semi-finished materials
Mechanical properties
Medical sciences
microtubular scaffold
Miscellaneous
Morphology
nerve tissue engineering
P19 cell
polyhydroxybutyrate
Polymer industry, paints, wood
Polymers
solid liquid phase separation
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology of polymers
Technology. Biomaterials. Equipments
Tissue engineering
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Summary:In this study, we fabricated PHB scaffolds by solid/liquid phase separation method. The properties of fabricated scaffolds were investigated using SEM, DMTA, and DSC. Our studies noticed that for an approach to scaffolds that contain tubular morphology and better mechanical properties, the solution should be frozen near crystallization temperature. For in vitro evaluation, the P19 mouse embryonal cell line was used as a model system. Results notice that cells attach and differentiate to the nerve cell. In vitro assay shows that it is a suitable model for use as a platform for neural tissue engineering applications.
ISSN:0091-4037
1563-535X
DOI:10.1080/00914037.2010.531809