Synthesis and Fluorescence Investigation of Differently Substituted Benzo[b][1,8]Naphthyridines: Interaction with Different Solvents and Bovine Serum Albumin (BSA)

• Published in: Journal of fluorescence 2011-05, Vol.21 (3), p.1033-1047
• Main Authors: Shelar, Deepak P., Patil, Sandeep R., Rote, Ramhari V., Toche, Raghunath B., Jachak, Madhukar N.
• Format: Article
• Language: English
• Subjects: Analytical Chemistry; Animals; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biomedicine; Biophysics; Biotechnology; Buffers; Condensing; Fluorescence; Naphthyridines - chemistry; Phosphates; Rapid Communication; Serum albumin; Serum Albumin, Bovine - chemistry; Solvents; Solvents - chemistry; Spectrometry, Fluorescence - methods; Spectrophotometry, Ultraviolet; Spectroscopy; Synthesis
• ISSN: 1053-0509; 1573-4994
• DOI: 10.1007/s10895-010-0783-1

A series of benzo[ b ][1, 8]naphthyridines has been synthesized by Friedländer condensation of 2-aminoquinoline-3-carbaldehyde 1 (o-aminoaldehyde) with active methylenes in basic medium. The fluorescence spectroscopic properties of some representative compounds has been studied in different organic solvents; moreover interaction with bovine serum albumin (BSA) in phosphate buffer was examined by UV–vis and fluorescence spectroscopy. The effect of electron donor-acceptor substituents on fluorescence properties of benzo[ b ][1, 8]naphthyridines 13(a-n) has been investigated along with their fluorescent quantum yields. Figure Synthesis and fluorescence investigation of benzo[ b ][1,8]naphthyridines