Difference between calculated and direct-measured low-density lipoprotein cholesterol in subjects with diabetes mellitus or taking lipid-lowering medications

Objective We evaluated factors that caused differences between calculated low-density lipoprotein cholesterol (C-LDL-C) and direct-measured LDL-C (D-LDL-C) and compared them in subjects with diabetes mellitus (DM) or taking lipid-lowering medications. Methods 21,452 subjects (9,177 women, 12,275 men...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical lipidology 2012-03, Vol.6 (2), p.114-120
Main Authors: Choi, Su-Yeon, MD, PhD, Park, Hyo Eun, MD, Kim, Min-Kyung, MD, Shin, Chan Soo, MD, PhD, Cho, Sang-Heon, MD, PhD, Oh, Byung-Hee, MD, PhD
Format: Article
Language:English
Subjects:
Blood Chemical Analysis - methods
Cardiovascular
Cholesterol, LDL - blood
Community-based study
Diabetes mellitus
Diabetes Mellitus - blood
Female
Friedewald formula
Humans
Hypolipidemic Agents - therapeutic use
Logistic Models
Low-density lipoprotein cholesterol
Male
Middle Aged
Triglyceride
Triglycerides - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective We evaluated factors that caused differences between calculated low-density lipoprotein cholesterol (C-LDL-C) and direct-measured LDL-C (D-LDL-C) and compared them in subjects with diabetes mellitus (DM) or taking lipid-lowering medications. Methods 21,452 subjects (9,177 women, 12,275 men; 8.1% with DM and 8.5% on lipid-lowering medications) were included in the analysis. Participants were classified into 3 groups, i.e., group 1: the subjects without DM and not on lipid-modifying drugs (n = 18,287), group 2: without DM and on lipid-modifying drugs (n = 1,423), and group 3: with DM (n = 1,742). LDL-C concentrations were either directly measured by a homogenous method or calculated by Friedewald formula. Results There was a significant correlation between C-LDL-C and D-LDL-C ( r = 0.966, P  
ISSN:1933-2874
1876-4789
DOI:10.1016/j.jacl.2011.12.007