Diterpenoids and triterpenoids with potential anti-inflammatory activity from the leaves of Aglaia odorata

• Published in: Phytochemistry (Oxford) 2012-04, Vol.76, p.83-91
• Main Authors: Yodsaoue, Orapun, Sonprasit, Jarinthon, Karalai, Chatchanok, Ponglimanont, Chanita, Tewtrakul, Supinya, Chantrapromma, Suchada
• Format: Article
• Language: English
• Subjects: Aglaia; Aglaia - chemistry; Aglaia odorata; Animals; Anti-inflammatory; anti-inflammatory activity; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - isolation & purification; Anti-Inflammatory Agents - pharmacology; Cell Line; Dammarane triterpenoid; Dinoprostone - chemistry; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenes - pharmacology; diterpenoids; Dolabellane diterpenoid; indomethacin; Indomethacin - pharmacology; Inhibitory Concentration 50; leaves; Lipopolysaccharides - adverse effects; Macrophages - drug effects; Magnetic Resonance Spectroscopy; medicinal plants; Meliaceae; Mice; Molecular Structure; nitric oxide; Nitric Oxide - chemistry; nuclear magnetic resonance spectroscopy; Plant Leaves - chemistry; Protostane triterpenoid; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology; triterpenoids
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2012.01.015

Chemical investigation of the leaves of the oriental medicinal plant Aglaia odorata resulted in the isolation of five compounds: two dolabellane diterpenoids (1, 2), two dammarane triterpenoids (6, 7) and a protostane triterpenoid (8), along with twenty known compounds. Eleven compounds possessed inhibitory activities against LPS-induced NO production in RAW264.7 cell lines with IC50 values ranging from 2.1 to 14.2μM). In addition three compounds exhibited significant activity against PGE2 release with IC50 values of 2.6, 16.1 and 23.0μM. [Display omitted] ► The leaves of Aglaia odorata were investigated. ► Five compounds of dolabellane, dammarane and protostane classes were isolated. ► The compounds exhibited potential anti-inflammatory activity. Chemical investigation of the leaves of the oriental medicinal plant Aglaia odorata resulted in the isolation of five compounds: two dolabellane diterpenoids, two dammarane triterpenoids and a protostane triterpenoid, along with twenty known compounds. Their structures were elucidated on the basis of extensive spectroscopic analysis and by comparison of their NMR spectroscopic data with those reported in the literature. The anti-inflammatory activities of all compounds were evaluated as inhibitory activities against lipopolysaccharide (LPS) induced nitric oxide (NO) production in RAW264.7 cell lines. Eleven compounds possessed potent nitric oxide inhibitory activity with IC50 values ranging from 2.1 to 14.2μM, these being better than that of the positive control, indomethacin (IC50=14.5μM). In addition, three compounds exhibited significant activity against PGE2 release with IC50 values of 2.6, 16.1 and 23.0μM.