Chondroitin sulfate: A key molecule in the brain matrix

Chondroitin sulfate is a glycosaminoglycan composed of N-acetylgalactosamine and glucuronic acid. It attaches to a core protein to form chondroitin sulfate proteoglycan (CSPG). Being a major component of the brain extracellular matrix, CSPGs are involved in neural development, axon pathfinding and g...

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Bibliographic Details
Published in:The international journal of biochemistry & cell biology 2012-04, Vol.44 (4), p.582-586
Main Authors: Kwok, J.C.F., Warren, P., Fawcett, J.W.
Format: Article
Language:English
Subjects:
Animals
binding properties
biochemical pathways
brain
Brain - metabolism
Brain - physiology
Brain Injuries - metabolism
Brain Injuries - physiopathology
Central nervous system
Chondroitin sulfate
Chondroitin Sulfates - biosynthesis
Chondroitin Sulfates - chemistry
Chondroitin Sulfates - metabolism
extracellular matrix
Gene Expression Regulation
glucuronic acid
Humans
neurodevelopment
Neuronal Plasticity
Plasticity
proteoglycans
Regeneration
Spinal Cord Injuries - metabolism
Spinal Cord Injuries - physiopathology
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Summary:Chondroitin sulfate is a glycosaminoglycan composed of N-acetylgalactosamine and glucuronic acid. It attaches to a core protein to form chondroitin sulfate proteoglycan (CSPG). Being a major component of the brain extracellular matrix, CSPGs are involved in neural development, axon pathfinding and guidance, plasticity and also regeneration after injury in the nervous system. In this review, we shall discuss the structure, the biosynthetic pathway, its functions in the nervous system and how we can improve regeneration in the nervous system by modulating its structure and binding properties.
ISSN:1357-2725
1878-5875
DOI:10.1016/j.biocel.2012.01.004