Modification of chitosan membrane with poly(vinyl alcohol) and biocompatibility evaluation

► Chitosan had strong interactions with poly(vinyl alcohol) by forming hydrogen bond. ► Adding PVA into chitosan membrane could improve its flexibility and wettability. ► MTS cytotoxicity essay indicated CS/PVA membranes were biocompatible. ► Cells attachment studies showed CS/PVA membranes were bio...

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Bibliographic Details
Published in:International journal of biological macromolecules 2012-04, Vol.50 (3), p.658-663
Main Authors: Zhuang, Peng-Yu, Li, You-Liang, Fan, Li, Lin, Jun, Hu, Qiao-Ling
Format: Article
Language:English
Subjects:
alcohols
Biocompatibility
Cell Adhesion - drug effects
Cell Line, Tumor
chemical structure
Chitosan
Chitosan - chemistry
Chitosan - toxicity
contact angle
cytotoxicity
Fourier transform infrared spectroscopy
Humans
hydrophobicity
Materials Testing
mechanical properties
Membranes, Artificial
Poly(vinyl alcohol)
polyvinyl alcohol
Polyvinyl Alcohol - chemistry
scanning electron microscopy
Tensile Strength
thermal properties
Wettability
X-ray diffraction
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Summary:► Chitosan had strong interactions with poly(vinyl alcohol) by forming hydrogen bond. ► Adding PVA into chitosan membrane could improve its flexibility and wettability. ► MTS cytotoxicity essay indicated CS/PVA membranes were biocompatible. ► Cells attachment studies showed CS/PVA membranes were biocompatible. This work aimed to overcome chitosan (CS) membrane’ drawbacks: mainly stiffness and hydrophobic surface by adding poly(vinyl alcohol) (PVA) and evaluate their biocompatibility. The chemical structure, crystalline and thermal properties were studied by FT-IR, XRD and DSC. The mechanical properties and wettability of CS/PVA membranes were studied by tensile test and static contact angle measurement. In vitro biocompatibility was also evaluated by MTS cytotoxicity assay and SEM examination. The results suggest that adding PVA into CS membrane could greatly improve CS membrane's flexibility and wettability. All the membranes prepared were biocompatible and have potential applications in GTR technology.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2012.01.026