Renin-angiotensin system polymorphisms in relation to hypertension status and obesity in a Tunisian population

• Published in: Molecular biology reports 2012-04, Vol.39 (4), p.4059-4065
• Main Authors: Mehri, Sounira, Mahjoub, Sinda, Hammami, Sonia, Zaroui, Amira, Frih, Ameur, Betbout, Fathi, Mechmeche, Rachid, Hammami, Mohamed
• Format: Article
• Language: English
• Subjects: Aged; Angiotensinogen - genetics; Animal Anatomy; Animal Biochemistry; Biomedical and Life Sciences; Body Mass Index; Case-Control Studies; Confidence Intervals; Demography; Female; Genetic Predisposition to Disease; Genetics, Population; Histology; Humans; Hypertension; Hypertension - complications; Hypertension - genetics; Life Sciences; Logistic Models; Male; Middle Aged; Molecular biology; Morphology; Obesity; Obesity - complications; Obesity - genetics; Odds Ratio; Peptidyl-Dipeptidase A - genetics; Polymorphism; Polymorphism, Genetic; Population genetics; Receptor, Angiotensin, Type 1 - genetics; Renin-Angiotensin System - genetics; Risk Factors; Tunisia
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-011-1187-2

Essential hypertension (HTA) is the clinical expression of a disordered interaction between the genetic, physiological, and biochemical systems that under usual conditions maintain cardiovascular homeostasis. We studied the effects of the angiotensinogen M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of HTA and to evaluate the relationship between these polymorphisms and obesity. We performed AGT, ACE and AGTR genotyping in 142 hypertensive patients and 191 control subjects using PCR-RFLP methods and PCR, respectively. The three polymorphisms were significantly associated with HTA. Individuals carrying the mutated TT of AGT, DD of ACE and CC of AT1R genotypes had an 1.67 ( P  = 0.032), 3.09 ( P