Antiviral Properties of Polymeric Aziridine- and Biguanide-Modified Core–Shell Magnetic Nanoparticles

• Published in: Langmuir 2012-03, Vol.28 (9), p.4548-4558
• Main Authors: Bromberg, Lev, Bromberg, Daniel J, Hatton, T. Alan, Bandín, Isabel, Concheiro, Angel, Alvarez-Lorenzo, Carmen
• Format: Article
• Language: English
• Subjects: Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Aziridines - chemistry; Biguanides - chemistry; Chemistry; Colloidal state and disperse state; Exact sciences and technology; General and physical chemistry; Herpes simplex virus 1; Infectious pancreatic necrosis virus; Infectious pancreatic necrosis virus - drug effects; Magnetics; Nanoparticles - chemistry; Physical and chemical studies. Granulometry. Electrokinetic phenomena; Polyethyleneimine - chemistry; Polymers - chemistry; Viral hemorrhagic septicemia virus
• ISSN: 0743-7463; 1520-5827
• DOI: 10.1021/la205127x

Polycationic superparamagnetic nanoparticles (∼150–250 nm) were evaluated as virucidal agents. The particles possess a core–shell structure, with cores consisting of magnetite clusters and shells of functional silica covalently bound to poly(hexamethylene biguanide) (PHMBG), polyethyleneimine (PEI), or PEI terminated with aziridine moieties. Aziridine was conjugated to the PEI shell through cationic ring-opening polymerization. The nanometric core–shell particles functionalized with biguanide or aziridine moieties are able to bind and inactivate bacteriophage MS2, herpes simplex virus HSV-1, nonenveloped infectious pancreatic necrosis virus (IPNV), and enveloped viral hemorrhagic septicaemia virus (VHSV). The virus–particle complexes can be efficiently removed from the aqueous milieu by simple magnetocollection.