Non-viral environmental risk factors for nasopharyngeal carcinoma: A systematic review

Abstract This review aims to systematically summarize the epidemiological studies on nasopharyngeal carcinoma (NPC) conducted over the past half century, covering descriptive epidemiological studies and reports on non-viral risk factors. Multiple lines of epidemiologic evidence for established risk...

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Bibliographic Details
Published in:Seminars in cancer biology 2012-04, Vol.22 (2), p.117-126
Main Authors: Jia, Wei-Hua, Qin, Hai-De
Format: Article
Language:English
Subjects:
Carcinoma
Diet - adverse effects
Environment
Environmental Pollutants - poisoning
Epidemiology
Gene-Environment Interaction
Genetic Predisposition to Disease - genetics
Hematology, Oncology and Palliative Medicine
Humans
Interaction
Models, Biological
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - epidemiology
Nasopharyngeal Neoplasms - etiology
Nasopharyngeal Neoplasms - genetics
Non-viral environmental risk factors
Pathogenesis
Risk Factors
Smoking - adverse effects
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Summary:Abstract This review aims to systematically summarize the epidemiological studies on nasopharyngeal carcinoma (NPC) conducted over the past half century, covering descriptive epidemiological studies and reports on non-viral risk factors. Multiple lines of epidemiologic evidence for established risk factors are systematically presented in comprehensive tables. The potential interactions among environmental factors and genetic components, and also the impacts of parallel sequencing technology on the aetiology of NPC are discussed. Finally, we propose a modified model for the pathogenesis of nasopharyngeal carcinoma based on the current knowledge.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2012.01.009