Antinucleosome in systemic lupus erythematosus. A study in a Brazilian population

Antinucleosome antibodies have been found with variable prevalence in systemic lupus erythematosus (SLE) and were associated with more severe disease. This research aims to study the prevalence of antinucleosome antibodies in a sample of Brazilian adult SLE patients and their association with clinic...

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Bibliographic Details
Published in:Clinical rheumatology 2012-03, Vol.31 (3), p.553-556
Main Authors: Sardeto, G. A., Simas, L. M., Skare, T. S., Nisihara, R. M., Utiyama, S. R. R.
Format: Article
Language:English
Subjects:
Adult
Antibodies, Antinuclear - blood
Antibodies, Antinuclear - immunology
Brazil
Brief Report
Female
Humans
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - immunology
Male
Medicine
Medicine & Public Health
Middle Aged
Nucleosomes - immunology
Rheumatology
Severity of Illness Index
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Summary:Antinucleosome antibodies have been found with variable prevalence in systemic lupus erythematosus (SLE) and were associated with more severe disease. This research aims to study the prevalence of antinucleosome antibodies in a sample of Brazilian adult SLE patients and their association with clinical findings and disease activity. Ninety-two adult patients (81 females and 11 males, with mean age of 37.29 ± 10.98 years) with SLE were studied for clinical and antibody profile, disease activity by SLE disease activity index (SLEDAI), and presence of antinucleosome antibodies by ELISA. The prevalence of antinucleosome antibodies was 61.9% (mean titer, 87.8 ± 62.6 U). No relationship was found of antinucleosome presence and any of the studied clinical features. A positive association was detected with anti-DNA ( p  = 0.001) and SLEDAI ( p  
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-011-1889-9