Targeted endoradiotherapy using nucleotides

► Molecular targeting of proliferation. ► Radionuclides for internal radiotherapy. ► Radiation effects of radionuclide microirradiation with respect to DNA. ► Nucleosides for therapy. ► Perspective for the clinical use. Increased cellular proliferation is an integral part of the cancer phenotype. He...

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Bibliographic Details
Published in:Methods (San Diego, Calif.) Calif.), 2011-11, Vol.55 (3), p.203-214
Main Authors: Morgenroth, Agnieszka, Vogg, Andreas T., Mottaghy, Felix M., Schmaljohann, Jörn
Format: Article
Language:English
Subjects:
Animals
Auger emitter
Cell Proliferation - radiation effects
Endoradiotherapy
Humans
Nucleoside analogs
Nucleotides - administration & dosage
Radiation Dosage
Radiopharmaceuticals - administration & dosage
Radiotherapy - methods
α Emitter
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Summary:► Molecular targeting of proliferation. ► Radionuclides for internal radiotherapy. ► Radiation effects of radionuclide microirradiation with respect to DNA. ► Nucleosides for therapy. ► Perspective for the clinical use. Increased cellular proliferation is an integral part of the cancer phenotype. Hence, the sustained and continued demand on supply of DNA building blocks during the DNA replication presents a potential target for therapeutic intervention. For this propose, the α and Auger electron emitting nucleotides analogs are attractive for targeted endoradiotherapy, given that DNA of malignant cells is selectively addressed. This review summarizes development and preclinical and clinical studies of endoradiotherapeutic acting nucleoside analogs with a special focus on thymidine analogs.
ISSN:1046-2023
1095-9130
DOI:10.1016/j.ymeth.2011.06.009