Early age at menarche associated with increased all-cause mortality

The objective was to examine the association between age at menarche and all-cause mortality. A population-based prospective study involving 55,128 Japanese women aged 40-79 years in 1988-1990 and followed up to December 2006 was used. A total of 6,967 deaths occurred during the follow-up. Hazard ra...

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Bibliographic Details
Published in:European journal of epidemiology 2011-10, Vol.26 (10), p.771-778
Main Authors: Tamakoshi, Koji, Yatsuya, Hiroshi, Tamakoshi, Akiko
Format: Article
Language:English
Subjects:
Adult
Age
Age Factors
Aged
Biological and medical sciences
Body mass
Body mass index
Cardiology
Cause of Death
Cohort studies
Epidemiology
Female
Follow-Up Studies
General aspects
Graduate schools
Health risks
Humans
Infectious Diseases
Japan - epidemiology
Laboratory schools
Medical sciences
Medicine
Medicine & Public Health
Menarche
Menarche - physiology
Menopause
Middle Aged
Miscellaneous
Mortality
Mortality - trends
Mortality risk
Oncology
Parity
Predisposing factors
Proportional Hazards Models
Prospective Studies
Public Health
Public health. Hygiene
Public health. Hygiene-occupational medicine
Reproductive History
Research universities
Risk Factors
Smoking
Surveys and Questionnaires
Universities
Womens health
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Summary:The objective was to examine the association between age at menarche and all-cause mortality. A population-based prospective study involving 55,128 Japanese women aged 40-79 years in 1988-1990 and followed up to December 2006 was used. A total of 6,967 deaths occurred during the follow-up. Hazard ratios (HR) and 95% confidence intervals (CI) adjusted for age, smoking and drinking status, exercise, sleeping hours, parity, menopausal status, and body mass index at baseline were calculated by Cox proportional hazards model. The HRs (95% CI) of allcause mortality were 1.16 (1.01-1.32), 1.01 (0.92-1.11), 1.00, 0.97 (0.90-1.05), 0.98 (0.91-1.05), 0.92 (0.84-1.01), and 1.05 (0.96-1.14) for women with menarche aged 9-12, 13, 14 (referent), 15, 16, 17,18-20 years, respectively, indicating an inverse J-shaped association (P for quadratictrend
ISSN:0393-2990
1573-7284
DOI:10.1007/s10654-011-9623-0