Changes in the Activity of the Ciliary Apparatus of Ependymal Cells in the Midbrain Cerebral Aqueduct Induced by a Number of Cerebrospinal Fluid Neurotransmitters

Studies of the effects of neurotransmitter amino acids on the motor activity of the ciliary apparatus of ependymal cells of the midbrain cerebral aqueduct in neonatal white mice showed that addition of glutamate, GABA-aminobutyric acid, glycine, and taurine to the culture medium induced slowing and...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2012, Vol.42 (1), p.72-74
Main Authors: Svanidze, I. K., Didimova, E. V., Gvinadze, N. N.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Amino acids
Behavioral Sciences
Bicuculline
Biomedical and Life Sciences
Biomedicine
Cell culture
Cerebrospinal fluid
Cilia
Cytotoxicity
Ependymal cells
Experiments
Glutamic acid
Glycine
Ion channels
Ketamine
Mesencephalon
Motor activity
Neonates
Nervous system
Neurobiology
Neurosciences
Neurotransmitters
Physiology
strychnine
Taurine
Transmitters
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Summary:Studies of the effects of neurotransmitter amino acids on the motor activity of the ciliary apparatus of ependymal cells of the midbrain cerebral aqueduct in neonatal white mice showed that addition of glutamate, GABA-aminobutyric acid, glycine, and taurine to the culture medium induced slowing and then complete cessation of the activity of the ciliary apparatus. Inhibition and cessation of the activity of cilia in response to neurotransmitters, especially glutamate at high concentrations, demonstrated the existence of the corresponding receptors on the membranes of ependymal cells in the cerebral aqueduct, and this was supported by experiments with prior addition of ion channel blockers to the growth medium, i.e., ketamine, strychnine, and bicuculline, which weakened the destructive influences of neurotransmitters and increased the duration of functioning of the ciliary apparatus.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-011-9536-0