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Melanization of a Meristematic Mutant of Fonsecaea monophora Increases Tolerance to Stress Factors While no Effects on Antifungal Susceptibility
Melanin is a complex polymer, which is widely distributed in nature, and is known as an important virulence factor in opportunistic and pathogenic fungi. In this study, three melanin mutants of Fonsecaea monophora from a case of chromoblastomycosis were generated from a parent strain that lacked hyp...
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| Published in: | Mycopathologia (1975) 2011-11, Vol.172 (5), p.373-380 |
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| Main Authors: | , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c475t-bb8a36d69fc75e69f194bd49bd12e823bf163c14a1aa5a6e37511998a363458f3 |
| container_end_page | 380 |
| container_issue | 5 |
| container_start_page | 373 |
| container_title | Mycopathologia (1975) |
| container_volume | 172 |
| creator | Sun, Jiufeng Zhang, Junmin Najafzadeh, M. J. Badali, Hamid Li, Xiqing Xi, Liyan de Hoog, G. S. |
| description | Melanin is a complex polymer, which is widely distributed in nature, and is known as an important virulence factor in opportunistic and pathogenic fungi. In this study, three melanin mutants of
Fonsecaea monophora
from a case of chromoblastomycosis were generated from a parent strain that lacked hyphal morphology but was meristematic instead. Two albino mutants, one of which (CBS 125187) produced secreted melanin and another (CBS 125149) lacked melanin, grew faster than a mutant with cell-wall-associated and secreted melanin (CBS 125188) and than the meristematic parent strain (CBS 122845) (
P
|
| doi_str_mv | 10.1007/s11046-011-9439-1 |
| format | article |
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Fonsecaea monophora
from a case of chromoblastomycosis were generated from a parent strain that lacked hyphal morphology but was meristematic instead. Two albino mutants, one of which (CBS 125187) produced secreted melanin and another (CBS 125149) lacked melanin, grew faster than a mutant with cell-wall-associated and secreted melanin (CBS 125188) and than the meristematic parent strain (CBS 122845) (
P
< 0.05). The albino strains were also more sensitive to low pH, high UV radiation, and oxidative stress (
P
< 0.05). However, susceptibility testing against eight antifungal agents showed no statistical difference (
P
> 0.05). The discovery of three melanin mutants of a single meristematic mutant provided an alternative way to study the role of cell-wall-associated and secreted melanins in the pathogenesis of black fungi.</description><identifier>ISSN: 0301-486X</identifier><identifier>EISSN: 1573-0832</identifier><identifier>DOI: 10.1007/s11046-011-9439-1</identifier><identifier>PMID: 21706309</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Aged, 80 and over ; Albinism ; Antifungal agents ; Antifungal Agents - pharmacology ; Ascomycota - drug effects ; Ascomycota - genetics ; Ascomycota - growth & development ; Ascomycota - physiology ; Base Sequence ; Biodiversity ; Biomedical and Life Sciences ; Chromoblastomycosis - microbiology ; Eukaryotic Microbiology ; Fonsecaea ; Fungi ; Humans ; Hydrogen-Ion Concentration ; Life Sciences ; Male ; Medical Microbiology ; Melanins - genetics ; Melanins - metabolism ; Microbial Ecology ; Microbiology ; Mutation ; Nuclear radiation ; Oxidative Stress ; Parasitology ; Pathogenesis ; Pigmentation - genetics ; Plant Sciences ; Sequence Analysis, DNA ; Stress, Physiological - genetics ; Temperature ; Ultraviolet Rays ; Virulence</subject><ispartof>Mycopathologia (1975), 2011-11, Vol.172 (5), p.373-380</ispartof><rights>Springer Science+Business Media B.V. 2011</rights><rights>COPYRIGHT 2011 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-bb8a36d69fc75e69f194bd49bd12e823bf163c14a1aa5a6e37511998a363458f3</citedby><cites>FETCH-LOGICAL-c475t-bb8a36d69fc75e69f194bd49bd12e823bf163c14a1aa5a6e37511998a363458f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21706309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Jiufeng</creatorcontrib><creatorcontrib>Zhang, Junmin</creatorcontrib><creatorcontrib>Najafzadeh, M. J.</creatorcontrib><creatorcontrib>Badali, Hamid</creatorcontrib><creatorcontrib>Li, Xiqing</creatorcontrib><creatorcontrib>Xi, Liyan</creatorcontrib><creatorcontrib>de Hoog, G. S.</creatorcontrib><title>Melanization of a Meristematic Mutant of Fonsecaea monophora Increases Tolerance to Stress Factors While no Effects on Antifungal Susceptibility</title><title>Mycopathologia (1975)</title><addtitle>Mycopathologia</addtitle><addtitle>Mycopathologia</addtitle><description>Melanin is a complex polymer, which is widely distributed in nature, and is known as an important virulence factor in opportunistic and pathogenic fungi. In this study, three melanin mutants of
Fonsecaea monophora
from a case of chromoblastomycosis were generated from a parent strain that lacked hyphal morphology but was meristematic instead. Two albino mutants, one of which (CBS 125187) produced secreted melanin and another (CBS 125149) lacked melanin, grew faster than a mutant with cell-wall-associated and secreted melanin (CBS 125188) and than the meristematic parent strain (CBS 122845) (
P
< 0.05). The albino strains were also more sensitive to low pH, high UV radiation, and oxidative stress (
P
< 0.05). However, susceptibility testing against eight antifungal agents showed no statistical difference (
P
> 0.05). The discovery of three melanin mutants of a single meristematic mutant provided an alternative way to study the role of cell-wall-associated and secreted melanins in the pathogenesis of black fungi.</description><subject>Aged, 80 and over</subject><subject>Albinism</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - pharmacology</subject><subject>Ascomycota - drug effects</subject><subject>Ascomycota - genetics</subject><subject>Ascomycota - growth & development</subject><subject>Ascomycota - physiology</subject><subject>Base Sequence</subject><subject>Biodiversity</subject><subject>Biomedical and Life Sciences</subject><subject>Chromoblastomycosis - microbiology</subject><subject>Eukaryotic Microbiology</subject><subject>Fonsecaea</subject><subject>Fungi</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Melanins - genetics</subject><subject>Melanins - metabolism</subject><subject>Microbial Ecology</subject><subject>Microbiology</subject><subject>Mutation</subject><subject>Nuclear radiation</subject><subject>Oxidative Stress</subject><subject>Parasitology</subject><subject>Pathogenesis</subject><subject>Pigmentation - genetics</subject><subject>Plant Sciences</subject><subject>Sequence Analysis, DNA</subject><subject>Stress, Physiological - genetics</subject><subject>Temperature</subject><subject>Ultraviolet Rays</subject><subject>Virulence</subject><issn>0301-486X</issn><issn>1573-0832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkl1rFDEUhgdR7Fr9Ad5I8KZ4MTVnMh_J5VK6utBFcCt6FzLZk23KTLImGbD-Cn-yGbYqFURycSDnec8Xb1G8BHoOlHZvIwCt25IClKJmooRHxQKajpWUs-pxsaCMQlnz9stJ8SzGW0qzCrqnxUkFHW0ZFYvixwYH5ex3lax3xBuiyAaDjQnH_KXJZkrKpTmx8i6iVqjI6J0_3PigyNrpgCpiJNd-wKCcRpI82aaAMZKV0smHSD7f2AGJ8-TSGNQpktxp6ZI1k9urgWynqPGQbG8Hm-6eF0-MGiK-uI-nxafV5fXF-_Lqw7v1xfKq1HXXpLLvuWLtrhVGdw3mAKLud7Xod1Ahr1hvoGUaagVKNapF1jUAQswiVjfcsNPi7Fj3EPzXCWOSo81zDPka6KcoRdVyXomm_i_JBc-1WdNm8vVf5K2fgstrZKjjrIFqhs6PUN4dpXXGp6B0fjscrfYOTb6WXLJGQFcB51nw5oEgMwm_pb2aYpTr7ceHLBxZHXyMAY08BDuqcCeBytkz8ugZmT0jZ89IyJpX91NP_Yi734pfJslAdQRiTrk9hj9r_bvqTy6mzEE</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Sun, Jiufeng</creator><creator>Zhang, Junmin</creator><creator>Najafzadeh, M. J.</creator><creator>Badali, Hamid</creator><creator>Li, Xiqing</creator><creator>Xi, Liyan</creator><creator>de Hoog, G. S.</creator><general>Springer Netherlands</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20111101</creationdate><title>Melanization of a Meristematic Mutant of Fonsecaea monophora Increases Tolerance to Stress Factors While no Effects on Antifungal Susceptibility</title><author>Sun, Jiufeng ; Zhang, Junmin ; Najafzadeh, M. J. ; Badali, Hamid ; Li, Xiqing ; Xi, Liyan ; de Hoog, G. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-bb8a36d69fc75e69f194bd49bd12e823bf163c14a1aa5a6e37511998a363458f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged, 80 and over</topic><topic>Albinism</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - pharmacology</topic><topic>Ascomycota - drug effects</topic><topic>Ascomycota - genetics</topic><topic>Ascomycota - growth & development</topic><topic>Ascomycota - physiology</topic><topic>Base Sequence</topic><topic>Biodiversity</topic><topic>Biomedical and Life Sciences</topic><topic>Chromoblastomycosis - microbiology</topic><topic>Eukaryotic Microbiology</topic><topic>Fonsecaea</topic><topic>Fungi</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Melanins - genetics</topic><topic>Melanins - metabolism</topic><topic>Microbial Ecology</topic><topic>Microbiology</topic><topic>Mutation</topic><topic>Nuclear radiation</topic><topic>Oxidative Stress</topic><topic>Parasitology</topic><topic>Pathogenesis</topic><topic>Pigmentation - genetics</topic><topic>Plant Sciences</topic><topic>Sequence Analysis, DNA</topic><topic>Stress, Physiological - genetics</topic><topic>Temperature</topic><topic>Ultraviolet Rays</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Jiufeng</creatorcontrib><creatorcontrib>Zhang, Junmin</creatorcontrib><creatorcontrib>Najafzadeh, M. 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J.</au><au>Badali, Hamid</au><au>Li, Xiqing</au><au>Xi, Liyan</au><au>de Hoog, G. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Melanization of a Meristematic Mutant of Fonsecaea monophora Increases Tolerance to Stress Factors While no Effects on Antifungal Susceptibility</atitle><jtitle>Mycopathologia (1975)</jtitle><stitle>Mycopathologia</stitle><addtitle>Mycopathologia</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>172</volume><issue>5</issue><spage>373</spage><epage>380</epage><pages>373-380</pages><issn>0301-486X</issn><eissn>1573-0832</eissn><abstract>Melanin is a complex polymer, which is widely distributed in nature, and is known as an important virulence factor in opportunistic and pathogenic fungi. In this study, three melanin mutants of
Fonsecaea monophora
from a case of chromoblastomycosis were generated from a parent strain that lacked hyphal morphology but was meristematic instead. Two albino mutants, one of which (CBS 125187) produced secreted melanin and another (CBS 125149) lacked melanin, grew faster than a mutant with cell-wall-associated and secreted melanin (CBS 125188) and than the meristematic parent strain (CBS 122845) (
P
< 0.05). The albino strains were also more sensitive to low pH, high UV radiation, and oxidative stress (
P
< 0.05). However, susceptibility testing against eight antifungal agents showed no statistical difference (
P
> 0.05). The discovery of three melanin mutants of a single meristematic mutant provided an alternative way to study the role of cell-wall-associated and secreted melanins in the pathogenesis of black fungi.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>21706309</pmid><doi>10.1007/s11046-011-9439-1</doi><tpages>8</tpages></addata></record> |
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| source | Springer Nature |
| subjects | Aged, 80 and over Albinism Antifungal agents Antifungal Agents - pharmacology Ascomycota - drug effects Ascomycota - genetics Ascomycota - growth & development Ascomycota - physiology Base Sequence Biodiversity Biomedical and Life Sciences Chromoblastomycosis - microbiology Eukaryotic Microbiology Fonsecaea Fungi Humans Hydrogen-Ion Concentration Life Sciences Male Medical Microbiology Melanins - genetics Melanins - metabolism Microbial Ecology Microbiology Mutation Nuclear radiation Oxidative Stress Parasitology Pathogenesis Pigmentation - genetics Plant Sciences Sequence Analysis, DNA Stress, Physiological - genetics Temperature Ultraviolet Rays Virulence |
| title | Melanization of a Meristematic Mutant of Fonsecaea monophora Increases Tolerance to Stress Factors While no Effects on Antifungal Susceptibility |
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