Non-hemolytic [small alpha]-AApeptides as antimicrobial peptidomimetics

We report a new class of peptide mimetics, [small alpha]-AApeptides, that display broad-spectrum activity against both Gram-negative and Gram-positive bacteria and fungi. With non-hemolytic activity, resistance to protease hydrolysis, and easy sequence programmability, [small alpha]-AApeptides may e...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (34), p.9729-9731
Main Authors: Padhee, Shruti, Hu, Yaogang, Niu, Youhong, Bai, Ge, Wu, Haifan, Costanza, Frankie, West, Leigh, Harrington, Lacey, Shaw, Lindsey N, Cao, Chuanhai, Cai, Jianfeng
Format: Article
Language:English
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Summary:We report a new class of peptide mimetics, [small alpha]-AApeptides, that display broad-spectrum activity against both Gram-negative and Gram-positive bacteria and fungi. With non-hemolytic activity, resistance to protease hydrolysis, and easy sequence programmability, [small alpha]-AApeptides may emerge as a novel class of antibiotics.
ISSN:1359-7345
DOI:10.1039/C1CC13684D