Substituted Quinolinones. Part 16. Preparation and reactions of 3-(4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropano i c acid

Preparation of quinolinyl-3-oxopropanoic acid was accomplished by hydrolysis of pyranoquinolinedione, in aqueous alkaline medium. The chemical behavior of this ?-keto acid towards nitrosation, coupling with a diazonium salt, esterification, condensation with 2,2-diethoxyethanamine, hydrazinolysis, K...

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Bibliographic Details
Published in:European journal of chemistry 2011-09, Vol.2 (3), p.378-387
Main Authors: Abass, Mohamed, Mohamed, Elhossain Ali, Ismail, Mostafa Mohamed, Mayas, Aisha Saleh
Format: Article
Language:English
Online Access:Get full text
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Summary:Preparation of quinolinyl-3-oxopropanoic acid was accomplished by hydrolysis of pyranoquinolinedione, in aqueous alkaline medium. The chemical behavior of this ?-keto acid towards nitrosation, coupling with a diazonium salt, esterification, condensation with 2,2-diethoxyethanamine, hydrazinolysis, Knoevenagel condensation with isatine, salicylaldehyde, 3-formylquinolones, and 3-formylchromone, was investigated. Also many of the products of these reactions were obtained using either pyranoquinolinedione 1 or ?-keto acid 2, under the same conditions.
ISSN:2153-2249
2153-2257
DOI:10.5155/eurjchem.2.3.378-387.351