Detection of torque teno midi virus/small anellovirus (TTMDV/SAV) in chronic cervicitis and cervical tumors in Isfahan, Iran

Torque teno midi virus and small anellovirus (TTMDV/SAV) are members of the genus Gammatorquevirus within the family Anelloviridae . Cervical cancer is the second most prevalent cancer after breast cancer. The aim of this study was to determine the frequency of infection by these viruses in cervicit...

Full description

Saved in:
Bibliographic Details
Published in:Archives of virology 2012-02, Vol.157 (2), p.291-295
Main Authors: Salmanizadeh, Sharareh, Bouzari, Majid, Talebi, Ardeshir
Format: Article
Language:English
Subjects:
Bacterial diseases
Bacterial diseases of the genital system
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Breast cancer
Carcinogenesis, carcinogens and anticarcinogens
Carcinoma, Squamous Cell - virology
Cervical cancer
Ethanol
Female
Fundamental and applied biological sciences. Psychology
Hepatitis
Hospitals
Human bacterial diseases
Humans
Infections
Infectious Diseases
Iran
Medical Microbiology
Medical sciences
Microbiology
Miscellaneous
Molecular Sequence Data
Original Article
Phylogeny
Thermal cycling
Torque teno virus - classification
Torque teno virus - genetics
Torque teno virus - isolation & purification
Tumors
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - virology
Uterine Cervicitis - virology
Viral infections
Virology
Viruses
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Torque teno midi virus and small anellovirus (TTMDV/SAV) are members of the genus Gammatorquevirus within the family Anelloviridae . Cervical cancer is the second most prevalent cancer after breast cancer. The aim of this study was to determine the frequency of infection by these viruses in cervicitis and cervical tumors of women from Isfahan, Iran. Formalin-fixed, paraffin-embedded tissue samples from cervical cancers (n = 42) and cervicitis cases (n = 79) were subjected to nested PCR to identify TTMDV/SAV viral sequences. Of the 42 tumor cases, 22, 18 and 2 were diagnosed as adenocarcinoma, cervical intraepithelial neoplasia and squamous cell carcinoma, respectively. In total, 23 (55%) of the tumor samples were positive for TTMDV/SAV. Of the 79 cervicitis cases, 38 (48%) were also positive for TTMDV/SAV. This is the first report of TTMDV/SAV in cervicitis and cervical tumors of women.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-011-1169-7