Effects of protamine hydrochloride from chum salmon milt on lipid metabolism in rats

Protamine is a basic protein whose sulfate is used in medical applications as a carrier for injectable insulin and as a heparin antagonist, while its hydrochloride is used as an antibacterial ingredient for some food products. We previously showed that protamine hydrochloride derived from chum salmo...

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Bibliographic Details
Published in:Fisheries science 2011-11, Vol.77 (6), p.1045-1052
Main Authors: Takahashi, Yoshinori, Konishi, Tatsuya, Enari, Hiroyuki, Lee, Heon-sik, Lee, Won Kyung, Lee, Young Sun, Park, Hyoung Kook, Yamamoto, Shigeru
Format: Article
Language:English
Subjects:
Adipose tissue
Amino acids
Anticoagulants
Biomedical and Life Sciences
Body fat
Body weight
Calories
Cholesterol
Diet
Feces
Fish & Wildlife Biology & Management
Fishery sciences
Food
Food additives
Food Science
Freshwater & Marine Ecology
Functional foods & nutraceuticals
High density lipoprotein
Insulin
Laboratory animals
Life Sciences
Lipids
Liver
Metabolism
Nutrition research
Obesity
Oils & fats
Oncorhynchus keta
Oral administration
Original Article
Plasma
Proteins
Salmon
Salmonidae
Studies
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Summary:Protamine is a basic protein whose sulfate is used in medical applications as a carrier for injectable insulin and as a heparin antagonist, while its hydrochloride is used as an antibacterial ingredient for some food products. We previously showed that protamine hydrochloride derived from chum salmon milt inhibited pancreatic lipase and reduced plasma triacylglycerol levels in an oral fat tolerance test in humans. The present study evaluated the effect of chum protamine hydrochloride on lipid metabolism in rats. The single oral administration of protamine hydrochloride (500 mg/kg) reduced plasma triacylglycerol levels in a corn oil tolerance test, and repeated oral administration at a dose of 0, 150, 500, or 1,500 mg/kg with a high fat diet for 7 weeks significantly reduced body weight gain, liver weight, and epididymal adipose tissue, whereas total calorie intakes were not significantly different. These findings could be caused by the suppression of lipid digestibility leading to a significant increase in fecal lipid excretion due to the fact that protamine hydrochloride could bind with bile acids to make a complex that is difficult to digest. Protamine hydrochloride, with a considerable history as food, can be considered to be promising as an anti-obesity functional food material.
ISSN:0919-9268
1444-2906
DOI:10.1007/s12562-011-0399-7