Module-assisted preparation of 64Cu with high specific activity

In this work the production of 64Cu via the 64Ni(p,n)64Cu reaction with optimized conditions for low current irradiation is presented. Different target setups and cleaning steps for lowering metal contaminations in the product were applied. 64Cu with high specific activities up to 1685GBq/μmol was p...

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Bibliographic Details
Published in:Applied radiation and isotopes 2012-04, Vol.70 (4), p.602-608
Main Authors: Thieme, S., Walther, M., Pietzsch, H.-J., Henniger, J., Preusche, S., Mäding, P., Steinbach, J.
Format: Article
Language:English
Subjects:
64Cu
Automation
Copper Radioisotopes - chemistry
Cyclotron
Nickel
PET imaging
Radioactive Waste - prevention & control
Radioactivity
Radiopharmaceuticals - chemical synthesis
Radiotherapy
Targetry
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Summary:In this work the production of 64Cu via the 64Ni(p,n)64Cu reaction with optimized conditions for low current irradiation is presented. Different target setups and cleaning steps for lowering metal contaminations in the product were applied. 64Cu with high specific activities up to 1685GBq/μmol was produced despite low overall activity (∼4.2GBq per run). The module processing leads to a highly reproducible, reliable product quality (
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2012.01.019