An eye on RNAi in nematode parasites

RNA interference (RNAi) has revolutionised approaches to gene function determination. From a parasitology perspective, gene function studies have the added dimension of providing validation data, increasingly deemed essential to the initial phases of drug target selection, pre-screen development. No...

Full description

Saved in:
Bibliographic Details
Published in:Trends in parasitology 2011-11, Vol.27 (11), p.505-513
Main Authors: Maule, Aaron G, McVeigh, Paul, Dalzell, Johnathan J, Atkinson, Louise, Mousley, Angela, Marks, Nikki J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Caenorhabditis elegans
Caenorhabditis elegans - genetics
drugs
eyes
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
General aspects
genes
Genes, Helminth - genetics
Genomics
Humans
Infectious Disease
Infectious diseases
Invertebrates
Medical sciences
Nemathelminthia. Plathelmintha
Nematoda
Nematoda - genetics
parasites
Parasitic diseases
parasitology
Phenotype
Plants - parasitology
Reproducibility of Results
RNA Interference
RNA, Double-Stranded - genetics
RNA, Helminth - genetics
RNA, Helminth - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:RNA interference (RNAi) has revolutionised approaches to gene function determination. From a parasitology perspective, gene function studies have the added dimension of providing validation data, increasingly deemed essential to the initial phases of drug target selection, pre-screen development. Notionally advantageous to those working on nematode parasites is the fact that Caenorhabditis elegans research spawned RNAi discovery and continues to seed our understanding of its fundamentals. Unfortunately, RNAi data for nematode parasites illustrate variable and inconsistent susceptibilities which undermine confidence and exploitation. Now well-ensconced in an era of nematode parasite genomics, we can begin to unscramble this variation.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2011.07.004