Transcription of Aspergillus nidulans pacC is modulated by alternative RNA splicing of palB

► The PacC/Pal transduction pathway mediates metabolic responses to pH sensing. ► The pacC gene is modulated by nutrient changes, phosphate and carbon sources, and pH. ► Alternative splicing of palB is predominant in MM, affecting transcription of pacC. ► The transcription of pacC is downregulated i...

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Bibliographic Details
Published in:FEBS letters 2011-11, Vol.585 (21), p.3442-3445
Main Authors: Trevisan, Glauce L., Oliveira, Ernna H.D., Peres, Nalu T.A., Cruz, Aline H.S., Martinez-Rossi, Nilce M., Rossi, Antonio
Format: Article
Language:English
Subjects:
Alternative Splicing - drug effects
Alternative Splicing - genetics
Aspergillus nidulans
Aspergillus nidulans - drug effects
Aspergillus nidulans - genetics
Carbon - pharmacology
Cysteine Endopeptidases - deficiency
Cysteine Endopeptidases - genetics
Fungal Proteins - genetics
Gene Expression Regulation, Fungal - drug effects
Gene Expression Regulation, Fungal - genetics
Hydrogen-Ion Concentration
Mutation
pacC
palB
pH Regulation
Phosphate regulation
Phosphates - pharmacology
Real-Time Polymerase Chain Reaction
RNA splicing
Transcription Factors - genetics
Transcription, Genetic - drug effects
Transcription, Genetic - genetics
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Summary:► The PacC/Pal transduction pathway mediates metabolic responses to pH sensing. ► The pacC gene is modulated by nutrient changes, phosphate and carbon sources, and pH. ► Alternative splicing of palB is predominant in MM, affecting transcription of pacC. ► The transcription of pacC is downregulated in a palB7 background. ► Transcription of pacC gene is greatly reduced in high-Pi MM cultures at pH 5.0. Fungi have evolved elaborate signal transduction networks for remodeling metabolic pathways to scavenge nutrients, including the secretion of nutritional enzymes. This adaptive response involves the conserved PacC/Pal signal transduction pathway, which mediates the transcriptional response to ambient pH. In this study, we show that transcription of the gene for PacC is modulated in response to nutrient changes, phosphate and carbon sources, and pH. In addition, we show that transcription of pacC is modulated in response to alternative RNA splicing of the palB gene. These results reveal novel aspects of the complex network involved in modulation of pacC.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2011.09.037