A toolbox to study liver stage malaria

The first obligatory phase of mammalian infection by Plasmodium parasites, the causative agents of malaria, occurs in the liver of the host. This stage of Plasmodium infection bears enormous potential for anti-malarial intervention. Recent technological progress has strongly contributed to overcomin...

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Bibliographic Details
Published in:Trends in parasitology 2011-12, Vol.27 (12), p.565-574
Main Authors: Prudêncio, Miguel, Mota, Maria M, Mendes, António M
Format: Article
Language:English
Subjects:
Animals
antimalarials
Biological and medical sciences
Disease Models, Animal
Flow Cytometry
Gastroenterology and Hepatology
General aspects
Host-Parasite Interactions
Human protozoal diseases
Humans
Infectious Disease
Infectious diseases
liver
Liver - parasitology
Liver - pathology
Luminescence
Malaria
Malaria - parasitology
Malaria - pathology
Malaria - prevention & control
mammals
Medical sciences
Microscopy - methods
parasites
Parasitic diseases
parasitology
Plasmodium
Plasmodium - physiology
Plasmodium - ultrastructure
Protozoal diseases
Real-Time Polymerase Chain Reaction
researchers
Sporozoites - physiology
Sporozoites - ultrastructure
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Summary:The first obligatory phase of mammalian infection by Plasmodium parasites, the causative agents of malaria, occurs in the liver of the host. This stage of Plasmodium infection bears enormous potential for anti-malarial intervention. Recent technological progress has strongly contributed to overcoming some of the long-standing difficulties in experimentally assessing hepatic infection by Plasmodium . Here, we review appropriate infection models and infection assessment tools, and provide a comprehensive description of recent advances in experimental strategies to investigate the liver stage of malaria. These issues are discussed in the context of current challenges in the field to provide researchers with the technical tools that enable effective experimental approaches to study liver stage malaria.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2011.09.004