Synthesis and antimicrobial evaluation of some new polyheterocyclic systems containing 1,2,4-triazine moiety

7-(4-Chloro/3-nitrophenyl)-8-[5,6-diphenyl-4-(1,3-thiazol-2-yl)-1, 4-di hydro-1,2,4-triazin-3-yl]-5-oxo-1,5-dihydro[1,2,4]triazolo[1,5-a]p y r idine-6-carbonitrile (6a, b) was utilized as a key intermediate for the target polyheterocyclic systems. Reactions of 6a, b with halocarbonyl reagents follow...

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Bibliographic Details
Published in:European journal of chemistry 2010-09, Vol.1 (3), p.168-172
Main Author: Abdel-Monem, Wafaa Ramzy
Format: Article
Language:English
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Summary:7-(4-Chloro/3-nitrophenyl)-8-[5,6-diphenyl-4-(1,3-thiazol-2-yl)-1, 4-di hydro-1,2,4-triazin-3-yl]-5-oxo-1,5-dihydro[1,2,4]triazolo[1,5-a]p y r idine-6-carbonitrile (6a, b) was utilized as a key intermediate for the target polyheterocyclic systems. Reactions of 6a, b with halocarbonyl reagents followed by heterocyclization with bi-nitrogen nucleophiles gave some new nitrogen heterocycles (7-13). Structures of the new compounds were established by elemental analyses and spectral data. The synthesized compounds were screened for their antimicrobial activity.
ISSN:2153-2249
2153-2257
DOI:10.5155/eurjchem.1.3.168-172.29