Systematic Approaches to Toxicology in the Zebrafish

As the current paradigms of drug discovery evolve, it has become clear that a more comprehensive understanding of the interactions between small molecules and organismal biology will be vital. The zebrafish is emerging as a complement to existing in vitro technologies and established preclinical in...

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Bibliographic Details
Published in:Annual review of pharmacology and toxicology 2012-01, Vol.52 (1), p.433-453
Main Authors: PETERSON, Randall T, MACRAE, Calum A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Carcinogenicity Tests
Danio rerio
Drug Delivery Systems
Drug Design
Drug Discovery
Drug Evaluation, Preclinical - methods
Freshwater
Gastrointestinal Tract - drug effects
General aspects. Methods
General pharmacology
Heart - drug effects
Liver - drug effects
Medical sciences
Models, Animal
Muscles - drug effects
Neurons - drug effects
Pharmaceutical Preparations
Pharmaceutical technology. Pharmaceutical industry
Pharmacokinetics
Pharmacology. Drug treatments
Phenotype
Toxicity Tests
Toxicology
Zebrafish
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Summary:As the current paradigms of drug discovery evolve, it has become clear that a more comprehensive understanding of the interactions between small molecules and organismal biology will be vital. The zebrafish is emerging as a complement to existing in vitro technologies and established preclinical in vivo models that can be scaled for high-throughput. In this review, we highlight the current status of zebrafish toxicology studies, identify potential future niches for the model in the drug development pipeline, and define the hurdles that must be overcome as zebrafish technologies are refined for systematic toxicology.
ISSN:0362-1642
1545-4304
DOI:10.1146/annurev-pharmtox-010611-134751